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Human NFKB1 Protein expressed in Wheat germ - ABIN1312483
Park, Hong, Park, Yoon, Seo, Hyun, Han, Ham, Hwang, Hong: Anticancer effect of tectochrysin in colon cancer cell via suppression of NF-kappaB activity and enhancement of death receptor expression. in Molecular cancer 2015
14-3-3zeta promotes esophageal squamous cell carcinoma invasion by repressing S1PR2 protein expression through NF-kappaB signaling
MIF, through CD74, constitutively activates NF-kappaB to control mitochondrial dynamics and stability for promoting carcinogenesis via averting apoptosis
identifies EBP1 as a novel pluripotency cofactor and provides insight into potential mechanisms used by DPPA4 in regulating pluripotency through its association with EBP1
CIRP mediates the activation of STAT3-Bag-1 signaling cascade via activating the Janus kinase family proteins and NF-kappaB signaling pathways upon UV irradiation.
A core element of NF-kappaB activation is the IKK complex built from two catalytic subunits, IKKa and IKKb kinases, and a regulatory subunit, NF-kappaB essential modulator (NEMO)/IKKc. (Review)
NF-kappaB1 polymorphism rs72696119 and related factors seemed associated with the susceptibility to HCV infection among high-risk Chinese populations.
Pretransplantation screening for NFKB1 -94ins/delATTG polymorphism may predict Cytomegalovirus infection and improve the management of patients at higher risk of infection in the post-kidney transplant period.
SPOP inhibits NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity and its target genes expression via FADD in non-small cell lung cancer
The role of NF-kappaB signaling in the ZBTB7 mediated 5fluorouracil drug resistance in colorectal cancer cells.
NF-KB p50 involvement in colorectal cancer development, through its engagement in the protumor activation of macrophages, identifies it as a candidate for prognostic and target therapeutic intervention.
review highlights and dissects the physiological role of NF-kappaB from its pathological role in the brain and delineates both, its beneficial as well as deleterious, role in the etiopathogenesis of Alzheimer's disease.
review the vast array of information supporting a detrimental role of RAGE/NF-kappaB axis activation in Alzheimer Disease brain and discuss those data in the context of recent findings pointing to an unexpected effect elicited by this signaling pathway which may rather contribute to reparative mechanisms in AD, namely positive modulation of adult neurogenesis.
Studies show that nuclear factor kappa B (NF-kappaB) signaling pathways mediated by B cell activating factor (BAFF) involve in B cell survival [Review].
HMGB1 silencing promotes tumor cells viability and arrest of pro-apoptotic proteins via Stat3/NFkappaB signaling in HepG2 cells.
In summary, we report that 25(OH)D concentrations in young healthy adults were positively associated with NFkappaB activity in PBMCs, but not associated with plasma pro- and anti-inflammatory markers.
Here, the authors show that the translesion DNA polymerase (Pol) kappa, a DinB orthologue, has a unique role in both protecting and restarting stalled replication forks under conditions of nucleotide deprivation.
NF-kappaB signaling pathway n glioblastoma under hypoxic conditions.CCL20 up-regulates HIF-1alpha through NF-kappaB activation.
NCOA1 interacts with NF-kappaB to increase VEGFC levels in human thyroid cancer.
High NFKB1 expression is associated with Osteoarthritis.
High NFKB1 expression is associated with Invasive Bladder Cancer.
These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB activation through a mechanism partly dependent on PPARgamma activation.
Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF expression through the activation of AP-1 and NF-kappaB in bovine mammary gland fibroblasts.
Data indicate the involvement of PKC-alpha in proMMP-2 activation and inhibition of TIMP-2 expression by NF-kappaB-MT1-MMP-dependent and -independent pathway.
MMP-1 promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 and activation of NF-kappaB
dynamic compression stimulates cell proliferation and proteoglycan synthesis in the presence of IL-1beta and/or inhibitors of the MAPKs and NFkappaB and AP-1 signalling pathways
TRIM5alpha represses HIV-1 LTR promoter activity by negatively regulating TAK1/TAB1/TAB2/TAB3-complex-mediated NF-kappaB activation.
Actinobacillus pleuropneumoniae induces alveolar Macrophages to produce proinflammatory cytokines via upregulation of TLR4 and NF-kappaB.
Here, heat shock protein 27 (Hsp27) has been identified as a novel binding partner of NS5A, a protein functioning in classical swine fever virus genome replication. Further findings clearly demonstrate that the inhibition of viral replication by Hsp27 is mediated via the NF-kappaB signaling pathway.
Porcine parvovirus virus infection significantly induced IL-6 expression and this induction depended on NF-kappaB activation and TLR9 signaling pathways in PK-15 cell.
This study showed that porcine epidemic diarrhea virus inhibited NF-kappaB activity and nsp1 was a potent NF-kappaB antagonist for suppression of both interferon and early production of pro-inflammatory cytokines.
inhibition of NF-kappaB increases autophagy via JNK signaling, and promotes steroidogenesis in porcine granulosa cells
SIRT1, p53 and NF-kappaB are involved in the control of both the proliferation and the apoptosis of ovarian cells.
porcine CD74 significantly enhanced the inflammatory response by regulating the NF-kappaB signalling pathway during PCV2 infection, which suggests that porcine CD74 may be implicated in the pathogenesis of PCV2 infection.
These results suggest that trans-10, cis-12-conjugated linoleic acid can modulate TNF-alpha production and NF-kappa B expression by a PPARgamma-dependent pathway in porcine peripheral blood mononuclear cells.
These results reveal the roles for NF-kappaB during different phases of neocortical gliogenesis and identify NF-kappaB as an inhibitor of early oligodendrocyte development in the cerebral cortex.
Furanodien-6-one from Commiphora erythraea inhibits the NF-kappaB signalling and attenuates LPS-induced neuroinflammation.
MicroRNA-326 aggravates acute lung injury in septic shock by mediating the NF-kappaB signaling pathway via BCL2A1.
High NFKB1expression is associated with Osteoarthritis.
Reducing NF-kappaB activation attenuates PDLIM2 deficiency-exacerbated inflammation and dyslipidemia in Palmitate -treated primary hepatocytes.
Findings confirm that signalling through MyD88 is the primary driver for Lipopolysaccharide-dependent NF-kappaB translocation to the nucleus. The pattern of NF-kappaB dynamics in TRIF-deficient cells does not, however, directly reflect the kinetics of TNFalpha promoter activation, supporting the concept that TRIF-dependent signalling plays an important role in the transcription of this cytokine.
Chandipura virus infection triggered the activation of signalling pathways mediated by mitogen-activated protein kinases, including p38, JNK 1 and 2, and nuclear factor kappaB.
These findings provide mechanistic insight into how polymorphisms that attenuate NFKB1 expression predispose humans to epithelial cancers, highlighting the pro-tumorigenic activity of STAT1 and identifying targetable vulnerabilities in GC.
Macrophage-derived IL1B/NF-kappaB signaling mediates parenteral nutrition-associated cholestasis in a mouse model.
SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NF-kappaB pathway in mouse Kupffer cells.
activation of NF-kappaB pathway is essential for Bacterial lipoprotein tolerance-augmented antimicrobial activity in innate phagocytes and depends primarily on both NOD1 and NOD2.
High host NF-kappaB p50 induces murine glioblastoma tumor.
NF-kappaB is responsible for Morgana dependent metastasis.
study indicates that downregulation of NF-kappaB1 can suppress renal cell carcinoma tumorigenesis by inducing late apoptosis/necrosis
TNF-alpha is involved in cardiac PHLPP1 upregulation during reoxygenation, which is mediated by NF-kappaB transcriptional activity
Nuclear Factor kappa B (NF-kappaB) pathway in the bone marrow (BM) vascular niche is a critical signalling axis that regulates haematopoietic stem cells (HSCs) function.
NF-kappaB and survivin are coordinately up-regulated in GBM patient tumors, and functional inhibition of either protein or BRD4 in in vitro and in vivo models restores sensitivity to EGFR tyrosine kinase inhibitors
NF-kappaB1 phosphorylation is regulated by platelet-activating factor in macrophages.
Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-kappaB signaling suppression.
Study indicate an essential role of NF-kappaB in gonadal differentiation.
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
DNA binding factor KBF1
, DNA-binding factor KBF1
, nuclear factor NF-kappa-B p105 subunit
, nuclear factor NF-kappa-B p50 subunit
, nuclear factor kappa-B DNA binding subunit
, nuclear factor of kappa light chain gene enhancer in B-cells 1, p105
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
, NF-kB p50 subunit
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
, nuclear factor kappa-B, subunit 1
, nuclear factor of kappa light polypeptide enhancer in B-cells 1
, nuclear factor kappa-B 1
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
, nuclear factor NF-kappa-B p105 subunit-like
, NF kappaB1
, NF-kappa-B1 p84/NF-kappa-B1 p98
, NF-kappaB p50
, nuclear factor kappaB p50
, nuclear factor-kappaB p50
, p50 subunit of NF kappaB
, p50 subunit of NF-kappaB
, BICD-related protein 1
, NF-kB1 precursor protein
, bicaudal D-related protein 1
, coiled-coil domain-containing protein 64A