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Human NFKB1 Protein expressed in Wheat germ - ABIN1312483
Park, Hong, Park, Yoon, Seo, Hyun, Han, Ham, Hwang, Hong: Anticancer effect of tectochrysin in colon cancer cell via suppression of NF-kappaB activity and enhancement of death receptor expression. in Molecular cancer 2015
In ovarian serous carcinoma, NF-kappaB nuclear expression correlated with the 4th edition WHO grade and PR was a favorable prognostic factor for ovarian serous carcinoma.
Findings indicate epigenetic regulation of E3 ubiquitin ligase (show MUL1 Proteins) KPC1 (show RNF123 Proteins) associated with NF-kappa B (NF-kappaB) pathway activation, promoting metastatic melanoma progression.
Here, the authors report that LRP16 selectively interacts and activates double-stranded RNA-dependent kinase (PKR (show PKLR Proteins)), and also acts as scaffolds to assist the formation of a ternary complex of PKR (show PKLR Proteins) and IKKbeta (show IKBKB Proteins), prolonging the polymers of ADP-ribose (PAR (show JTB Proteins))-dependent nuclear factor kappa B (NF-kappaB) transactivation caused by DNA-damaging agents and confers acquired chemoresistance.
Studied association between nuclear factor kappa beta1/IKK epsilon (show IKBKE Proteins) (NF-kappaB1/IKKepsilon (show IKBKE Proteins)) gene expression and clinical activity in rheumatoid arthritis (RA). Found there were significant differences in NF-kappaB1 and IKKepsilon (show IKBKE Proteins) gene expression (P = .001 and P = .029, respectively) between RA patients with clinical activity and clinical remission.
The functional -94 ins (show INS Proteins)/del ATTG polymorphism in the promoter region of human nuclear factor-kappa B1 (NFKB1) gene may be associated with cancer risk.
Rab27A (show RAB27A Proteins) is mediated by NF-kappaB and promotes stemness of colon cancer cells via up-regulation of cytokine secretion
These data suggest that TLR2 activation is involved in the induction of IL-15 (show IL15 Proteins) production by primary Sjogren's syndrome salivary gland epithelial cells and promotes inflammation through NF-kappaB activation.
Lipid oxidation product 4-hydroxy-2-nonenal is at the crossroads of NF-kappaB pathway and anti-apoptotic Bcl2 (show BCL2 Proteins) expression. (Review)
NKILA is a vital determinant of tongue squamous cell carcinoma cell migration and invasion; the NF-kappaB signaling pathway mediates this effect
Data show that p50 (show CD40 Proteins) is important as a unique mechanism of R-CHOP (show DDIT3 Proteins)-resistance in activated B-cell-like diffuse large B-cell lymphoma and in patients without TP53 (show TP53 Proteins) mutations.
These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB activation through a mechanism partly dependent on PPARgamma (show PPARG Proteins) activation.
Taken together, Staphylococcus aureus induces TGF-beta1 (show TGFB1 Proteins) and bFGF (show FGF2 Proteins) expression through the activation of AP-1 (show JUN Proteins) and NF-kappaB in bovine mammary gland fibroblasts.
Data indicate the involvement of PKC-alpha (show PKCa Proteins) in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Proteins) expression by NF-kappaB-MT1-MMP (show MMP14 Proteins)-dependent and -independent pathway.
MMP-1 (show MMP1 Proteins) promotes VEGFR2 (show KDR Proteins) expression and proliferation of endothelial cells through stimulation of PAR-1 (show F2R Proteins) and activation of NF-kappaB
dynamic compression stimulates cell proliferation and proteoglycan (show Vcan Proteins) synthesis in the presence of IL-1beta (show IL1B Proteins) and/or inhibitors of the MAPKs and NFkappaB and AP-1 (show JUN Proteins) signalling pathways
TRIM5alpha (show TRIM5 Proteins) represses HIV-1 LTR promoter activity by negatively regulating TAK1 (show NR2C2 Proteins)/TAB1 (show TAB1 Proteins)/TAB2 (show TAB2 Proteins)/TAB3 (show TAB3 Proteins)-complex-mediated NF-kappaB activation.
Here, heat shock protein 27 (Hsp27) has been identified as a novel binding partner of NS5A, a protein functioning in classical swine fever virus genome replication. Further findings clearly demonstrate that the inhibition of viral replication by Hsp27 is mediated via the NF-kappaB signaling pathway.
Porcine parvovirus virus infection significantly induced IL-6 (show IL6 Proteins) expression and this induction depended on NF-kappaB activation and TLR9 (show TLR9 Proteins) signaling pathways in PK-15 cell.
This study showed that porcine epidemic diarrhea virus inhibited NF-kappaB activity and nsp1 was a potent NF-kappaB antagonist for suppression of both interferon (show IFNA Proteins) and early production of pro-inflammatory cytokines.
inhibition of NF-kappaB increases autophagy via JNK (show MAPK8 Proteins) signaling, and promotes steroidogenesis in porcine granulosa cells
SIRT1 (show SIRT1 Proteins), p53 (show TP53 Proteins) and NF-kappaB are involved in the control of both the proliferation and the apoptosis of ovarian cells.
porcine CD74 (show CD74 Proteins) significantly enhanced the inflammatory response by regulating the NF-kappaB signalling pathway during PCV2 infection, which suggests that porcine CD74 (show CD74 Proteins) may be implicated in the pathogenesis of PCV2 infection.
These results suggest that trans-10, cis (show CISH Proteins)-12-conjugated linoleic acid can modulate TNF-alpha (show TNF Proteins) production and NF-kappa B expression by a PPARgamma (show PPARG Proteins)-dependent pathway in porcine peripheral blood mononuclear cells.
This is the first report demonstrating that NF-kappaB signaling may play a key role in compensatory lung growth (CLG (show PLEKHG2 Proteins)). Given its pathway is crucial in tissue regeneration of various organs, NF-kappaB may shed light on identification of molecular triggers or clinically usable key regulators of CLG (show PLEKHG2 Proteins).
Abrogating ClC-3 (show CLCN3 Proteins) blunts lipopolysaccharide-induced Inflammation via blocking the TLR4 (show TLR4 Proteins)/NF-kappaB pathway.
miR-17 approximately 92 family clusters have a role in iNKT cell ontogenesis via modulation of TGF-beta (show TGFB1 Proteins) signaling
NF-kappaB1-mediated signaling regulates the development of gastric mucosal pathology following TAM (show CCNA1 Proteins) administration.
that TG2 (show TGM2 Proteins) depletion increases nuclear factor-kappaB (NF-kappaB) signaling
LRRK1 physically interacted and potently synergized with CARMA1 (show CARD11 Proteins) to enhance NF-kappaB activation.
NLRC5 knockout mice fed with high fat showed accelerated fibrosis and inflammation response by promoting alpha-SMA (show SMN1 Proteins), Collagen I, Collagen III, TLR4 (show TLR4 Proteins)/MyD88 (show MYD88 Proteins), phosphorylated IKKalpha (show CHUK Proteins), IkappaBalpha (show NFKBIA Proteins) and NF-kappaB expression.
The results obtained in the present study demonstrate for the first time that S100A8 (show S100A8 Proteins) as well as MyD88 (show MYD88 Proteins) and NF-B are activated by T3 and that these molecules are directly involved in the thyroid hormone (show PTH Proteins)-induced cardiac hypertrophic response. These data suggest that one of the mechanisms underlying T3-dependent cardiac hypertrophy/failure may involve the activation of an inflammatory pathway.
Our data suggest that rCC16 suppresses LPS (show TLR4 Proteins)-mediated inflammatory mediator TNF-alpha (show TNF Proteins), IL-6 (show IL6 Proteins), and IL-8 (show IL8 Proteins) production by inactivating NF-kappaB and p38 MAPK (show MAPK14 Proteins) but not AP-1 (show JUN Proteins) in RAW264.7 cells.
Our data indicate for the first time that the inflammasome is involved in the inflammatory response and cell death in hypoxia-induced beta cells through the ROS (show ROS1 Proteins)-TXNIP (show TXNIP Proteins)-NLRP3 (show NLRP3 Proteins) axis in vitro. This provides new insight into the relationship between hypoxia and inflammation in T2D.
Study indicate an essential role of NF-kappaB in gonadal differentiation.
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
DNA binding factor KBF1
, DNA-binding factor KBF1
, nuclear factor NF-kappa-B p105 subunit
, nuclear factor NF-kappa-B p50 subunit
, nuclear factor kappa-B DNA binding subunit
, nuclear factor of kappa light chain gene enhancer in B-cells 1, p105
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
, NF-kB p50 subunit
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
, nuclear factor kappa-B, subunit 1
, nuclear factor of kappa light polypeptide enhancer in B-cells 1
, nuclear factor kappa-B 1
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
, nuclear factor NF-kappa-B p105 subunit-like
, NF kappaB1
, NF-kappa-B1 p84/NF-kappa-B1 p98
, NF-kappaB p50
, nuclear factor kappaB p50
, nuclear factor-kappaB p50
, p50 subunit of NF kappaB
, p50 subunit of NF-kappaB
, BICD-related protein 1
, NF-kB1 precursor protein
, bicaudal D-related protein 1
, coiled-coil domain-containing protein 64A