anti-Rabbit p53 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended p53 Antibody (supplied by: Log in to see )

Antigen
Tumor Protein P53 (TP53) Antibodies
  • BCC7
  • LFS1
  • P53
  • TRP53
  • p53
  • Trp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • tp53
  • Xp53
  • TP53
  • tumor protein p53
  • cellular tumor antigen p53
  • transformation related protein 53
  • tumor protein p53 L homeolog
  • TP53
  • CpipJ_CPIJ002758
  • Tp53
  • tp53
  • Trp53
  • tp53.L
Epitope
AA 345-390, Wild Type
175
122
89
81
71
71
70
58
57
52
49
47
47
45
41
37
35
31
25
22
22
20
16
16
15
15
15
15
15
15
14
12
11
11
10
10
10
9
8
7
7
7
7
7
6
6
6
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rabbit, Rat (Rattus)
2331
505
427
182
119
93
84
83
33
23
20
20
19
16
15
14
6
4
4
4
3
3
3
2
1
1
Host
Rabbit
1332
1109
7
1
1
1
1
1
Clonality
Polyclonal
Conjugate
This p53 antibody is un-conjugated
82
77
64
52
46
45
45
31
31
26
25
25
25
25
24
24
24
23
20
19
18
14
14
14
14
14
12
7
5
5
5
5
5
5
5
5
4
3
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
1877
763
739
709
624
605
412
342
309
178
72
41
32
30
21
17
17
15
13
9
9
4
4
3
3
3
2
1
1
1
1
1
1
1
1
1
1
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Catalog No. ABIN677408
$ 318.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN5668086 ELISA IF IHC (fro) IHC (p) IP in vivo WB Rabbit IgG, kappa AA 371-380 Log in to see Chimeric 0
1 ABIN5668085 ELISA IF IHC (fro) IHC (p) IP in vivo WB Mouse IgG2a, kappa AA 371-380 Log in to see PAb421 0
1 ABIN5681487 ELISA IF IHC (fro) IHC (p) in vivo WB Rabbit IgG kappa AA 371-380, C-Term Log in to see PAb421 0

General

Antigen Tumor Protein P53 (TP53) Antibodies
Epitope AA 345-390, Wild Type
(175), (122), (89), (81), (71), (71), (70), (58), (57), (52), (49), (47), (47), (45), (41), (37), (35), (31), (25), (22), (22), (20), (16), (16), (15), (15), (15), (15), (15), (15), (14), (12), (11), (11), (10), (10), (10), (9), (8), (7), (7), (7), (7), (7), (6), (6), (6), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rabbit, Rat (Rattus)
(2331), (505), (427), (182), (119), (93), (84), (83), (33), (23), (20), (20), (19), (16), (15), (14), (6), (4), (4), (4), (3), (3), (3), (2), (1), (1)
Host Rabbit
(1332), (1109), (7), (1), (1), (1), (1), (1)
Clonality
Polyclonal
Conjugate This p53 antibody is un-conjugated
(82), (77), (64), (52), (46), (45), (45), (31), (31), (26), (25), (25), (25), (25), (24), (24), (24), (23), (20), (19), (18), (14), (14), (14), (14), (14), (12), (7), (5), (5), (5), (5), (5), (5), (5), (5), (4), (3), (2), (2), (2)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(1877), (763), (739), (709), (624), (605), (412), (342), (309), (178), (72), (41), (32), (30), (21), (17), (17), (15), (13), (9), (9), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-p53 Antibody

Target Details p53 Application Details Handling References for anti-p53 antibody (ABIN677408) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human P53
Isotype IgG

Target Details p53

Product Details anti-p53 Antibody Application Details Handling References for anti-p53 antibody (ABIN677408) Images back to top
Antigen
Alternative Name P53 (TP53 Antibody Abstract)
Background

Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Synonyms: P53, BCC7, LFS1, TRP53, Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53

Gene ID 7157
UniProt P04637
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy

Application Details

Product Details anti-p53 Antibody Target Details p53 Handling References for anti-p53 antibody (ABIN677408) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-p53 Antibody Target Details p53 Application Details References for anti-p53 antibody (ABIN677408) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-p53 antibody (ABIN677408)

Product Details anti-p53 Antibody Target Details p53 Application Details Handling Images back to top
Product cited in:

Zhang, Zhang, Liu, Huang, Zhang, Yi, Yao, Hu: "Therapeutic efficacy of paclitaxel and carboplatin via arterial or venous perfusion in rabbits with VX-2 tongue cancer." in: International journal of clinical and experimental medicine, Vol. 8, Issue 4, pp. 4979-88, 2015 Method employed by authors: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rabbit).

Images

Product Details anti-p53 Antibody Target Details p53 Application Details Handling References for anti-p53 antibody (ABIN677408) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Tumor Protein P53 (TP53) (AA 345-390), (Wild Type) antibody (ABIN677408) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-P53(wt-p5...
Immunohistochemistry (IHC) image for anti-Tumor Protein P53 (TP53) (AA 345-390), (Wild Type) antibody (ABIN677408) Formalin-fixed and paraffin embedded rat brain labeled with Anti-P53(wt-p53) Polyclon...
 image for anti-Tumor Protein P53 (TP53) (AA 345-390), (Wild Type) antibody (ABIN677408) MCF7 cells were fixed with 70% ice-cold methanol overnight at 4℃, permeabilized with ...