anti-Rat (Rattus) p53 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended p53 Antibody (supplied by: Log in to see )

Antigen
Tumor Protein P53 (TP53) Antibodies
  • BCC7
  • LFS1
  • P53
  • TRP53
  • p53
  • Trp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • tp53
  • Xp53
  • TP53
  • tumor protein p53
  • cellular tumor antigen p53
  • transformation related protein 53
  • tumor protein p53 L homeolog
  • TP53
  • CpipJ_CPIJ002758
  • Tp53
  • tp53
  • Trp53
  • tp53.L
Epitope
AA 240-290, Wild Type
169
125
78
74
72
71
70
59
58
54
46
45
43
37
36
34
34
25
24
24
22
22
21
21
16
15
15
15
15
15
15
14
13
13
13
12
11
10
9
9
8
8
8
8
7
7
7
7
7
7
7
6
6
6
6
6
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
2508
566
464
308
162
104
103
67
56
26
23
23
18
17
17
16
7
6
5
4
4
4
4
3
3
2
2
1
1
Host
Rabbit
1468
1156
7
5
1
1
1
1
Clonality
Polyclonal
Conjugate
This p53 antibody is un-conjugated
81
80
68
52
45
36
35
32
23
23
23
20
20
20
20
20
19
19
18
18
15
14
14
12
12
12
12
12
11
8
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
7
6
5
2
2
2
Application
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
2084
961
864
783
682
659
420
316
267
156
110
90
75
41
32
17
17
15
12
10
4
4
4
3
3
2
2
1
1
1
1
1
1
1
1
1
1
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Catalog No. ABIN723935
$ 318.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
14.5 ABIN967419 IHC (fro) IHC (p) IP WB Mouse IgG1 AA 14-289 Log in to see PAb 240 7
14.5 ABIN677408 IF (p) IHC (p) WB Rabbit IgG AA 345-390, Wild Type Log in to see Polyclonal 1
12.755764 ABIN5668086 ELISA IF IHC (fro) IHC (p) IP in vivo WB Rabbit IgG, kappa AA 371-380 Log in to see Chimeric 0
12.755764 ABIN5668085 ELISA IF IHC (fro) IHC (p) IP in vivo WB Mouse IgG2a, kappa AA 371-380 Log in to see PAb421 0
12.617413 ABIN1386190 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal 3
11.117413 ABIN499003 IHC (p) WB Rabbit Log in to see Polyclonal 0
11.117413 ABIN499004 IHC (p) WB Rabbit Log in to see Polyclonal 0
11.117413 ABIN498159 IF IHC (p) WB Rabbit Log in to see Polyclonal 0
11.117413 ABIN5557506 IHC (p) WB Rabbit IgG pSer392 Log in to see 3A1 0
10 ABIN702895 IF (p) IHC (p) WB Rabbit IgG AA 5-55, pSer20 Log in to see Polyclonal 0
7 ABIN2888497 ELISA IHC IHC (p) IP WB Rabbit IgG pSer15 Log in to see Polyclonal 0
7 ABIN272050 IF IHC (p) WB Rabbit Log in to see Polyclonal 0
7 ABIN318091 IHC (p) IP WB Rabbit pSer15 Log in to see Polyclonal 0
7 ABIN271765 IHC (p) WB Rabbit Log in to see Polyclonal 0
7 ABIN317853 IF IHC (p) WB Rabbit Log in to see Polyclonal 0
5.5 ABIN703000 IF (p) IHC (p) WB Rabbit IgG pThr18 Log in to see Polyclonal 1
4 ABIN967420 IHC (fro) IHC (p) IP WB Mouse IgG1 AA 14-289 Log in to see PAb 240 7
4 ABIN2879088 ELISA IF IHC IHC (p) WB Rabbit IgG AA 344-393 Log in to see Polyclonal 0
4 ABIN2879087 ELISA IF IHC IHC (p) WB Rabbit IgG AA 283-332 Log in to see Polyclonal 0
4 ABIN2878967 ELISA IF IHC IHC (p) WB Rabbit IgG AA 10-59 Log in to see Polyclonal 0

General

Antigen Tumor Protein P53 (TP53) Antibodies
Epitope AA 240-290, Wild Type
(169), (125), (78), (74), (72), (71), (70), (59), (58), (54), (46), (45), (43), (37), (36), (34), (34), (25), (24), (24), (22), (22), (21), (21), (16), (15), (15), (15), (15), (15), (15), (14), (13), (13), (13), (12), (11), (10), (9), (9), (8), (8), (8), (8), (7), (7), (7), (7), (7), (7), (7), (6), (6), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(2508), (566), (464), (308), (162), (104), (103), (67), (56), (26), (23), (23), (18), (17), (17), (16), (7), (6), (5), (4), (4), (4), (4), (3), (3), (2), (2), (1), (1)
Host Rabbit
(1468), (1156), (7), (5), (1), (1), (1), (1)
Clonality
Polyclonal
Conjugate This p53 antibody is un-conjugated
(81), (80), (68), (52), (45), (36), (35), (32), (23), (23), (23), (20), (20), (20), (20), (20), (19), (19), (18), (18), (15), (14), (14), (12), (12), (12), (12), (12), (11), (8), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (6), (5), (2), (2), (2)
Application Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(2084), (961), (864), (783), (682), (659), (420), (316), (267), (156), (110), (90), (75), (41), (32), (17), (17), (15), (12), (10), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Product Details anti-p53 Antibody

Target Details p53 Application Details Handling References for anti-p53 antibody (ABIN723935) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human P53
Isotype IgG
Plasmids, Primers & others

Target Details p53

Product Details anti-p53 Antibody Application Details Handling References for anti-p53 antibody (ABIN723935) Images back to top
Antigen
Alternative Name P53 Protein (TP53 Antibody Abstract)
Background

Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Subcellular location: Cytoplasm, Nucleus

Synonyms: P53, BCC7, LFS1, TRP53, Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53

Gene ID 7157
UniProt P04637
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy

Application Details

Product Details anti-p53 Antibody Target Details p53 Handling References for anti-p53 antibody (ABIN723935) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-p53 Antibody Target Details p53 Application Details References for anti-p53 antibody (ABIN723935) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-p53 antibody (ABIN723935)

Product Details anti-p53 Antibody Target Details p53 Application Details Handling Images back to top
Product cited in:

Wang, Liu, Liu, Chen, Liu, Kuang: "Hypoxia Inhibits Myogenic Differentiation through p53 Protein-dependent Induction of Bhlhe40 Protein." in: The Journal of biological chemistry, Vol. 290, Issue 50, pp. 29707-16, 2015 Method employed by authors: Western Blotting (WB) (Sample species: Mouse (Murine)).

Hong, Shen, Liu, Li, Huang, Shi: "Developmental toxicity of three hexabromocyclododecane diastereoisomers in embryos of the marine medaka Oryzias melastigma." in: Marine pollution bulletin, Vol. 101, Issue 1, pp. 110-8, 2015 Method employed by authors: Western Blotting (WB)

Chen, Shi, Liu, Fang, Zhang, Zhao: "Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis." in: BMC cancer, Vol. 12, pp. 464, 2012 Method employed by authors: Western Blotting (WB) (1:1000, Sample species: Human).

Carry, Banssillon: "[Intra-abdominal pressure]." in: Annales francaises d'anesthesie et de reanimation, Vol. 13, Issue 3, pp. 381-99, 1995 Method employed by authors: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)).

Images

Product Details anti-p53 Antibody Target Details p53 Application Details Handling References for anti-p53 antibody (ABIN723935) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Tumor Protein P53 (TP53) (AA 240-290), (Wild Type) antibody (ABIN723935) Formalin-fixed and paraffin embedded human ovarian carcinoma labeled with Rabbit Anti...
SDS-PAGE (SDS) image for anti-Tumor Protein P53 (TP53) (AA 240-290), (Wild Type) antibody (ABIN723935) 1 rat brain, L2 human colon carcinoma lysates probed (ABIN723935) at 1:200 in 4 °C. F...
Immunofluorescence (IF) image for anti-Tumor Protein P53 (TP53) (AA 240-290), (Wild Type) antibody (ABIN723935) Image kindly submitted by Piotr Mamczur from Wroclaw University. Immunofluorescent lo...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Tumor Protein P53 (TP53) (AA 240-290), (Wild Type) antibody (ABIN723935) Formalin-fixed and paraffin embedded human ovarian carcinoma labeled with Rabbit Anti...