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The expression of p53R2 was associated closely with the development and progression of lung sarcomatoid carcinoma.
p53R2 protein is overexpressed in early-stage cervical cancer and unravels some unconventional oncogenic functions of p53R2.
High RRM2B expression is associated with neoplasms.
Studied the expression of ribonucleotide reductase (RR) subunit p53R2 in nasopharyngeal carcinoma and its significance in the prognosis.
RRM1 (show RRM1 Proteins)/RRM2B enzyme is capable of retaining activity in hypoxia and therefore is favored over RRM1 (show RRM1 Proteins)/RRM2 (show RRM2 Proteins) in order to preserve ongoing replication and avoid the accumulation of DNA damage in hypoxic cells.
p53R2 acts as a positive regulator of TrxR2 (show TXNRD2 Proteins) activity in mitochondria both under normal physiological conditions and during the cellular response to DNA damage
Silencing of both PYCR1 (show PYCR1 Proteins) and PYCR2 (show PYCR2 Proteins) completely abolished anti-oxidation activity of RRM2B, demonstrating a functional collaboration of these metabolic enzymes in response to oxidative stress.
A newly discovered role of E2F1 (show E2F1 Proteins) in the regulation of p53R2 expression in DNA damage response.
analysis of caspase (show CASP3 Proteins)-dependent degradation of human R2 and p53R2 small subunits
in Turkish population p53R2 genotype distributions between head and neck squamous epithelial cell cancer patients and control groups were not statistically significantly different.
Rrm2b plays a crucial role in maintaining chromosomal stability and preventing chronic-inflammation-associated tumorigenesis.
Rrm2b deficiency caused higher rates of spontaneous mutation in the kidneys of Rrm2b-/- mice. p53R2 has a pivotal role in maintaining dNTP levels for repair of DNA in resting cells.
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.
ribonucleotide reductase M2 B (TP53 inducible)
, ribonucleoside-diphosphate reductase subunit M2 B
, TP53-inducible ribonucleotide reductase M2 B
, p53-inducible ribonucleotide reductase small subunit 2 homolog
, p53-inducible ribonucleotide reductase small subunit 2 short form beta
, p53-inducible ribonucleotide reductase small subunit 2-like protein