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|Antigen||serpin Peptidase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 (SERPINE1) Antibodies|
|Conjugate||This SERPINE1 antibody is un-conjugated Alternatives|
Blocking Antibody (Inhibition), ELISA, Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-SERPINE1 AntibodyTarget Details SERPINE1 Application Details Handling Images
|Immunogen||PAI1 antibody was raised in rabbit using highly pure recombinant human PAI-1 as the immunogen.|
|Plasmids, Primers & others|
Target Details SERPINE1Product Details anti-SERPINE1 Antibody Application Details Handling Images back to top
|Alternative Name||PAI1 (SERPINE1 Antibody Abstract)|
|Background||Plasminogen Activator Inhibitor-1 (PAI-1, Serpin E1) is a member of the serpin family of serine protease inhibitors, and is the primary inhibitor of urokinase and tissue plasminogen activator (tPA). PAI-1 is expressed predominantly in adipose, liver and vascular tissues, and is also produced by certain tumor cells. Elevated levels of PAI-1 are associated with obesity, diabetes and cardiovascular disease, and increased production of PAI-1 is induced by various obesity related factors such as TNFa, glucose, insulin, and very-low-density lipoprotein. The obesity related elevation of PAI-1 levels along with the consequential deficiency in plasminogen activators can lead directly to increased risk of thrombosis and other coronary diseases.|
|Molecular Weight||42.7 kDa (predicted detection band MW)|
|Pathways||p53 Signaling, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Autophagy, Smooth Muscle Cell Migration|
Application DetailsProduct Details anti-SERPINE1 Antibody Target Details SERPINE1 Handling Images back to top
ELISA: 0.5-2 µg/mL, Inhibition: >15 µg/mL, WB: 0.1-0.2 µg/mL
Optimal conditions should be determined by the investigator.
|Restrictions||For Research Use only|
HandlingProduct Details anti-SERPINE1 Antibody Target Details SERPINE1 Application Details Images back to top
|Buffer||Lyophilized from PBS, pH 7.2.|
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.
|Storage Comment||Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.|