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|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Antibodies|
|Conjugate||This TNFRSF10B antibody is conjugated to Alexa Fluor 594 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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Product Details anti-TNFRSF10B AntibodyTarget Details TNFRSF10B Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human DR5/CD262|
Target Details TNFRSF10BProduct Details anti-TNFRSF10B Antibody Application Details Handling Images back to top
|Alternative Name||DR5 (TNFRSF10B Antibody Abstract)|
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
Subcellular location: Extracellular
Synonyms: Death receptor 5, CD 262, CD262, CD262 antigen, Death domain containing receptor for TRAIL/Apo2L, Death receptor 5, DR 5, DR5, Fas like protein precursor, KILLER, KILLER/DR5, p53 regulated DNA damage inducible cell death receptor (killer), TNF related apoptosis inducing ligand receptor 2, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL R2, TRAIL receptor 2, TRAILR2, TRANCER, TRICK2, TRICK2A, TRICK2B, TRICKB, Tumor necrosis factor receptor like protein ZTNFR9, Tumor necrosis factor receptor superfamily member 10b, ZTNFR9.
|Research Area||Cancer, Growth Factors, Apoptosis/Necrosis, Death Receptors, Signaling|
|Pathways||p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity|
Application DetailsProduct Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Handling Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|