anti-Human TNFRSF10B antibody for Immunohistochemistry

Recommended TNFRSF10B Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Antibodies
  • TNFRSF10B
  • dr5
  • cd262
  • killer
  • trick2
  • trickb
  • xDR-M1
  • xDR-M2
  • ztnfr9
  • trailr2
  • trick2a
  • trick2b
  • CD262
  • DR5
  • KILLER
  • KILLER/DR5
  • TRAIL-R2
  • TRAILR2
  • TRICK2
  • TRICK2A
  • TRICK2B
  • TRICKB
  • ZTNFR9
  • Ly98
  • MK
  • tumor necrosis factor receptor superfamily, member 10b
  • tumor necrosis factor receptor superfamily member 10b S homeolog
  • tumor necrosis factor receptor superfamily member 10b L homeolog
  • tumor necrosis factor receptor superfamily member 10b
  • TNF receptor superfamily member 10b
  • Tnfrsf10b
  • TNFRSF10B
  • tnfrsf10b.S
  • tnfrsf10b.L
  • tnfrsf10b
Reactivity
Human
302
69
29
2
1
1
1
1
Host
Mouse
183
147
8
6
2
Clonality
Monoclonal
Conjugate
This TNFRSF10B antibody is un-conjugated
19
18
16
6
5
4
4
4
4
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Functional Studies (Func), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP)
199
130
68
61
38
35
29
27
14
13
12
8
3
3
3
2
1
1
Options
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

Submit your validation data for this product and get a full refund. I want to validate this product

Learn more

Catalog No. ABIN1169245
$ 539.06
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
21.748539 ABIN1169244 FACS IHC Mouse IgG1 Log in to see TR2-21 0
15.755764 ABIN3021808 IHC WB Rabbit IgG Log in to see Polyclonal 0
14.492776 ABIN6265635 ELISA IHC WB Rabbit IgG Log in to see Polyclonal 1
13 ABIN1980532 ICC IHC WB Rabbit IgG AA 234-435 Log in to see Polyclonal 0
13 ABIN2904402 IF/ICC IHC IP WB Rabbit AA 234-435 Log in to see Polyclonal 0
12.992776 ABIN605169 IHC IHC (p) WB Rabbit IgG AA 380-398 Log in to see Polyclonal 0
12.755764 ABIN1169242 FACS Func ICC IHC IP Biotin Mouse IgG1 Log in to see HS201 0
9.992776 ABIN290834 FACS ICC IHC IHC (p) WB Rabbit IgG AA 388-407 Log in to see Polyclonal 0
9.992776 ABIN213934 ICC IF IHC IHC (p) WB Rabbit IgG C-Term Log in to see Polyclonal 0
9.992776 ABIN1502672 FACS IHC IHC (p) WB Rabbit Log in to see Polyclonal 0
7 ABIN1875126 IHC WB Rabbit IgG Log in to see Polyclonal 0
6.992776 ABIN2470152 ICC FACS IHC WB Rabbit IgG AA 388-407 Log in to see Polyclonal 0
4 ABIN342736 FACS IHC ELISA WB Goat Extracellular Domain Log in to see Polyclonal 0
4 ABIN791067 IHC ELISA WB Rabbit IgG Internal Region Log in to see Polyclonal 0
1 ABIN2629390 IHC IHC (p) WB Mouse IgG1 AA 203-411 Log in to see 1B9 0
1 ABIN2629388 IHC IHC (p) WB Rabbit IgG AA 333-348 Log in to see Polyclonal 0
1 ABIN2255639 IC FACS IHC ELISA WB Goat IgG Log in to see Polyclonal 0
1 ABIN2629397 FACS IHC IHC (p) Mouse IgG1 Log in to see TR2-21 0
1 ABIN961088 FACS IHC IHC (p) WB Rabbit AA 417-436 Log in to see Polyclonal 0
1 ABIN2882062 IHC WB Rabbit IgG Log in to see Polyclonal 0

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) Antibodies
Reactivity Human
(302), (69), (29), (2), (1), (1), (1), (1)
Host Mouse
(183), (147), (8), (6), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TNFRSF10B antibody is un-conjugated
(19), (18), (16), (6), (5), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS), Functional Studies (Func), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP)
(199), (130), (68), (61), (38), (35), (29), (27), (14), (13), (12), (8), (3), (3), (3), (2), (1), (1)
Pubmed 6 references available
Supplier Log in to see

Product Details anti-TNFRSF10B Antibody

Target Details TNFRSF10B Application Details Handling References for anti-TNFRSF10B antibody (ABIN1169245) Images
Specificity Recognizes human TRAIL-R2.
Cross-Reactivity Human
Cross-Reactivity (Details) Does not cross-react with human TRAIL-R1, -R3 or -R4.
Purification Purified from concentrated hybridoma tissue culture supernatant.
Purity >95 % (SDS-PAGE)
Immunogen Recombinant human TRAIL-R2 (DR5).
Clone HS201
Isotype IgG1
Plasmids, Primers & others

Target Details TNFRSF10B

Product Details anti-TNFRSF10B Antibody Application Details Handling References for anti-TNFRSF10B antibody (ABIN1169245) Images back to top
Antigen
Alternative Name TRAIL-R2 (TNFRSF10B Antibody Abstract)
Background TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
UniProt O14763
Pathways p53 Signaling, Apoptosis, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Handling References for anti-TNFRSF10B antibody (ABIN1169245) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details References for anti-TNFRSF10B antibody (ABIN1169245) Images back to top
Format Liquid
Concentration 1 mg/mL
Buffer In PBS containing 10 % glycerol and 0.02 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.
Expiry Date 12 months

References for anti-TNFRSF10B antibody (ABIN1169245)

Product Details anti-TNFRSF10B Antibody Target Details TNFRSF10B Application Details Handling Images back to top
Product cited in:

Ganten, Haas, Sykora, Stahl, Sprick, Fas, Krueger, Weigand, Grosse-Wilde, Stremmel, Krammer, Walczak: "Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs." in: Cell death and differentiation, Vol. 11 Suppl 1, pp. S86-96, 2004

Jin, Kurakin, Benhaga, Abe, Mohseni, Sandra, Song, Kay, Khosravi-Far: "Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5." in: The Journal of biological chemistry, Vol. 279, Issue 53, pp. 55594-601, 2004

Washburn, Weigand, Grosse-Wilde, Janke, Stahl, Rieser, Sprick, Schirrmacher, Walczak: "TNF-related apoptosis-inducing ligand mediates tumoricidal activity of human monocytes stimulated by Newcastle disease virus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 4, pp. 1814-21, 2003

Leverkus, Sprick, Wachter, Mengling, Baumann, Serfling, Bröcker, Goebeler, Neumann, Walczak: "Proteasome inhibition results in TRAIL sensitization of primary keratinocytes by removing the resistance-mediating block of effector caspase maturation." in: Molecular and cellular biology, Vol. 23, Issue 3, pp. 777-90, 2003

Sprick, Rieser, Stahl, Grosse-Wilde, Weigand, Walczak: "Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8." in: The EMBO journal, Vol. 21, Issue 17, pp. 4520-30, 2002

Higuchi, Yoon, Grambihler, Werneburg, Bronk, Gores: "Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis." in: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 454-61, 2002