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|Antigen||Cathepsin Z (CTSZ) Antibodies|
|Epitope||AA 1-306 Alternatives|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This Cathepsin Z antibody is un-conjugated Alternatives|
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Product Details anti-Cathepsin Z AntibodyTarget Details Cathepsin Z Application Details Handling Images
Mouse CTSZ / CTSX / Cathepsin Z
No cross-reactivity in ELISA with
|Characteristics||This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CTSZ / CTSX / Cathepsin Z (rM CTSZ / CTSX / Cathepsin Z, ABIN2007305 NP_071720.1, Met 1-Val 306,.|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Mouse CTSZ / CTSX / Cathepsin Z protein (ABIN2007305)|
Target Details Cathepsin ZProduct Details anti-Cathepsin Z Antibody Application Details Handling Images back to top
|Alternative Name||CTSZ (CTSZ Antibody Abstract)|
|Background||Cathepsin Z (CTSZ), also known as Cathepsin X or CATX, belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from other human cysteine proteases. It has a very short pro-region that shows no similarity to those of other cathepsins and a three-residue insertion motif that forms a characteristic 'mini loop'. Cathepsin Z exhibits mono- and di-peptidase activity at its C-terminus, and in contrast to cathepsin B, it does not act as an endopeptidase. It is restricted to the cells of theimmune system, predominantly monocytes, macrophages and dendritic cells. Cathepsin Z is widely expressed in human tissues, suggesting that this enzyme could be involved in the normal intracellular protein degradation taking place in all cell types. It is capable to cleave regulatory motifs at C-terminus affecting the function of targeted molecules. Cathepsin X may regulate also the maturation of dendritic cells, a process, which is crucial in the initiation of adaptive immunity. Furthermore, higher levels of Cathepsin Z are also found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa, especially after infection by Helicobacter pylori. Cathepsin Z is also ubiquitously distributed in cancer cell lines and in primary tumors from different sources, suggesting that this enzyme may participate in tumor progression.|
|Pathways||Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones|
Application DetailsProduct Details anti-Cathepsin Z Antibody Target Details Cathepsin Z Handling Images back to top
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse CTSZ. The detection limit for Mouse CTSZ is approximately 0.00975 ng/well.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Cathepsin Z Antibody Target Details Cathepsin Z Application Details Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|