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Human KLF4 Protein expressed in Wheat germ - ABIN1308754
Rivero, Díaz-Guerra, Monsalve, Laborda, García-Ramírez: DLK2 is a transcriptional target of KLF4 in the early stages of adipogenesis. in Journal of molecular biology 2012
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Human KLF4 Protein expressed in HEK-293 Cells - ABIN2724292
Boxer, Barajas, Tao, Zhang, Khavari: ZNF750 interacts with KLF4 and RCOR1, KDM1A, and CTBP1/2 chromatin regulators to repress epidermal progenitor genes and induce differentiation genes. in Genes & development 2014
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zebrafih Klf4a is essential for the repression of intestinal cell proliferation
Proper heart valve formation in zebrafish critically depends on protein kinase D2 (show PKD2 Proteins)-histone deacetylase 5 (show HDAC5 Proteins)-Kruppel-like factor signaling.
Here, the authors define WNT5A (show WNT5A Proteins), a non-canonical Wnt (show WNT2 Proteins) ligand implicated in epithelial differentiation, repair, and cancer, as a direct transcriptional target that is activated by KLF4 in squamous epithelial cells.
Results showed the expression levels of KLF4 were increased in bladder cancer (BC) patients which strongly correlated with the expression levels of PTBP1 (show PTBP1 Proteins) but inversely correlated with the expression level of miR (show MLXIP Proteins)-145. These findings suggest that KLF4 is likely to positively contribute to carcinogenesis in certain types of BC.
Transcriptional inhibition of MSI2 (show MSI2 Proteins) expression by KLF4 occurred in multiple PDAC cell lines as well as mouse models of PDAC. Lost expression of KLF4, a transcriptional repressor of MSI2 (show MSI2 Proteins) results in overexpression of MSI2 (show MSI2 Proteins) in PDACs, which may be a biomarker for accurate prognosis. A dysregulated KLF4/MSI2 (show MSI2 Proteins) signaling pathway promotes PDAC progression and metastasis.
the results of the present study demonstrated that by regulating KLF4, miR145 may be involved in regulating smooth muscle differentiation of ASCs induced by TGFbeta1 (show TGFB1 Proteins) and BMP4 (show BMP4 Proteins).
our findings reveal KLF4 as a key regulator of miR (show MLXIP Proteins)-182 cluster expression in hESCs and a main contributor to its aberrant expression in melanoma and potentially in other tumors
Surprisingly, 116 genes are directly activated via mCpG-dependent KLF4 binding activity. In-depth mechanistic studies reveal that recruitment of KLF4 to the methylated cis (show CISH Proteins)-regulatory elements of these genes result in chromatin remodeling and transcription activation.
KLF4 transcriptionally repressed FOXO1 (show FOXO1 Proteins) expression in glioma cells, contributing to glioma cell invasion and growth.
Data suggest that KLF4 could promote cell senescence through a complex network: miR (show MLXIP Proteins)-203, survivin (show BIRC5 Proteins), and p21 (show CDKN1A Proteins), which were all regulated by overexpression of KLF4 and contributed to cell senescence.
Our results establish KLF4alpha as a KLF4 isoform that opposes the function of KLF4(FL) and as an important factor in the complex and unresolved role of KLF4(FL) in breast carcinogenesis.
Kruppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation (show HELLS Proteins) and can be reversed by inhibition of NOTCH (show NOTCH1 Proteins) signaling.
Klf4 is transcribed both maternally and zygotically and the transcript is ubiquitous in embryos during germ-layer formation
miR (show MLXIP Proteins)-145 protects follicular granulosa cell against oxidative stress-induced (show SQSTM1 Proteins) apoptosis by targeting KLF4.
The results highlight a novel molecular mechanism underlying stability of neurogenesis-associated mRNAs controlled by the Klf4/Ddx5 (show DDX5 Proteins)/Stau1 (show STAU1 Proteins) axis during mammalian corticogenesis.
Analysis of tumor-infiltrating lymphocytes (TILs) demonstrated markedly increased activated CD8 (show CD8A Proteins) T cell numbers, and CD8 (show CD8A Proteins) T cell depletion obviated the inhibitory effect of myeloid Klf4 deletion on prostate cancer growth.
Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4 (show POU5F1 Proteins), c-Myc (show MYC Proteins), Sox2 (show SOX2 Proteins) and Klf4.
Based on these findings, we infer that MALAT1 is a transcriptional target of KLF4 in its protective role in cerebral MECs (show ISPF Proteins) after ischemic insult.
Folate receptor alpha (show FOLR1 Proteins) upregulates Oct4 (show POU5F1 Proteins), Sox2 (show SOX2 Proteins) and Klf4 and downregulates miR (show MLXIP Proteins)-138 and miR (show MLXIP Proteins)-let-7 in cranial neural crest cells.
overexpression of KLF4 promoted oligomeric Abeta42-induced neuroinflammation by exacerbating the release of pro-inflammatory factors
A long-range enhancer cluster controls Klf4 gene expression in mESCs
we revealed that one of the key functions of KLF4-induced TCL1 (show TCL1A Proteins) during reprogramming is to promote the metabolic shift from oxidative phosphorylation to glycolysis.
KLF4 modulates development of BMI1 (show BMI1 Proteins)-expressing intestinal stem cell-derived lineage following gamma-radiation-induced gut (show GUSB Proteins) injury in mice.
miR (show MYLIP Proteins)-92a coregulates KLF4 and KLF2 (show KLF2 Proteins) expression in arterial endothelium and contributes to phenotype heterogeneity associated with regional atherosusceptibility and protection in vivo.
a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene
Krueppel-like factor 4
, Kruppel-like transcription factor 4a
, Kruppel-like factor 4 (gut)
, Kruppel-like factor 4
, endothelial Kruppel-like zinc finger protein
, epithelial zinc finger protein EZF
, gut-enriched krueppel-like factor
, Kruppel-like transcription factor
, blood island enriched kruppel like factor
, Kruppel-like factor 4 (Gut enriched kruppel-like factor) (Epithelial zinc-finger protein EZF)