|Antigen||Proprotein Convertase Subtilisin/kexin Type 2 (PCSK2) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
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|Specificity||This antibody reacts to NEC 2.|
|Purification||Saturated Ammonium Sulfate (SAS) precipitation|
|Immunogen||KLH conjugated synthetic peptide selected from the N-terminal region of human PCSK2|
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|Alternative Name||NEC2 (PCSK2 Antibody Abstract)|
|Background||PCSK2 belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This protein is a proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. The protein is also known to cleave proopiomelanocortin, proenkephalin, prodynorphin and proluteinizing-hormone-releasing hormone.Synonyms: KEX2-like endoprotease 2, Neuroendocrine convertase 2, PCSK2, Prohormone convertase 2, Proprotein convertase 2|
|Pathways||Peptide Hormone Metabolism, cAMP Metabolic Process, Maintenance of Protein Location, Negative Regulation of Transporter Activity|
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ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
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|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|