Iodotyrosine Deiodinase (IYD) (N-Term) Peptide
IYD
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all IYD products
- IYD (Iodotyrosine Deiodinase (IYD))
- Protein Region
- N-Term
- Origin
- Human
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- NADRSMEKKK GEPRTRAEAR PWVDEDLKDS SDLHQAEEDA DEWQESEENV
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-IYD Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- IYD (Iodotyrosine Deiodinase (IYD))
- Synonyms
- MGC85450 Peptide, C6orf71 Peptide, DEHAL1 Peptide, TDH4 Peptide, dJ422F24.1 Peptide, 0610009A07Rik Peptide, AI265638 Peptide, Dehal1 Peptide, RGD1309288 Peptide, IYD-1 Peptide, iodotyrosine deiodinase Peptide, iodotyrosine deiodinase L homeolog Peptide, IYD Peptide, iyd.L Peptide, iyd Peptide, Iyd Peptide
- Background
-
This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4.
Alias Symbols: C6orf71, DEHAL1, TDH4, dJ422F24.1
Protein Size: 247 - Molecular Weight
- 27 kDa
- Gene ID
- 389434
- NCBI Accession
- NM_001164695, NP_001158167
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