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Non-SMC Element 4 Homolog A (NSMCE4A) (C-Term) Peptide

NSMCE4A Reactivity: Human Host: Synthetic BP, WB, ICC
Catalog No. ABIN2183687
  • Target See all NSMCE4A products
    NSMCE4A (Non-SMC Element 4 Homolog A (NSMCE4A))
    Protein Region
    C-Term
    Origin
    Human
    Source
    • 1
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB), Immunocytochemistry (ICC)
    Sequence
    PVIQEERAMP AQLRRMEESH QEATEKEVER ILGLLQTYFR EDPDTPMSFF
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-NSMCE4A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeat freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    NSMCE4A (Non-SMC Element 4 Homolog A (NSMCE4A))
    Synonyms
    2410003A14Rik Peptide, RGD1309025 Peptide, C10orf86 Peptide, NS4EA Peptide, NSE4A Peptide, NSE4 homolog A, SMC5-SMC6 complex component Peptide, Nsmce4a Peptide, NSMCE4A Peptide
    Background
    NSMCE4A is a component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). It is involved in positive regulation of response to DNA damage stimulus.

    Alias Symbols: C10orf86, NS4EA, NSE4A

    Protein Size: 385
    Molecular Weight
    44 kDa
    Gene ID
    54780
    NCBI Accession
    NM_017615, NP_060085
    UniProt
    Q9NXX6
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