V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) (Middle Region) Peptide
RAF1
Reactivity: Human
Host: Synthetic
BP, WB
-
- Target See all RAF1 products
- RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))
- Protein Region
- Middle Region
- Origin
- Human
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- SGTQEKNKIR PRGQRDSSYY WEIEASEVML STRIGSGSFG TVYKGKWHGD
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-RAF1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))
- Synonyms
- CRAF Peptide, NS5 Peptide, Raf-1 Peptide, c-Raf Peptide, c-raf Peptide, craf Peptide, raf1 Peptide, RAF1 Peptide, 6430402F14Rik Peptide, AA990557 Peptide, BB129353 Peptide, Craf1 Peptide, D830050J10Rik Peptide, v-Raf Peptide, raf Peptide, cRaf Peptide, Raf-1 proto-oncogene, serine/threonine kinase Peptide, Raf-1 proto-oncogene, serine/threonine kinase a Peptide, v-raf-leukemia viral oncogene 1 Peptide, Raf-1 proto-oncogene, serine/threonine kinase S homeolog Peptide, RAF1 Peptide, Raf1 Peptide, raf1a Peptide, raf1 Peptide, raf1.S Peptide
- Background
-
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Protein Size: 567 - Molecular Weight
- 62 kDa
- Gene ID
- 5894
- NCBI Accession
- XP_005265415
- UniProt
- B4E0X2
-
You are here:
