Dachshund Homolog 2 (Drosophila) (DACH2) (N-Term) Peptide

Details for Product No. ABIN691169, Supplier: Log in to see
Protein Name
  • 9430028N04Rik
  • RGD1561687
  • dachshund family transcription factor 2
  • dachshund 2 (Drosophila)
  • dachshund family transcription factor 2 L homeolog
  • dachshund homolog 2
  • dachshund homolog 2 (Drosophila)
  • DACH2
  • Dach2
  • dach2.L
  • LOC612847
  • dach2
Protein Region
N-Term
Source
Synthetic
Peptide Type
Synthetic
Application
Blocking Peptide (BP)
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Specificity The synthetic peptide sequence used to generate the antibody AP13241a was selected from the N-term region of DACH2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Protein Name
Background This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene.
Restrictions For Research Use only
Storage 4
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Styrkarsdottir, Halldorsson, Gretarsdottir, Gudbjartsson, Walters, Ingvarsson, Jonsdottir, Saemundsdottir, Snorradóttir, Center, Nguyen, Alexandersen, Gulcher, Eisman, Christiansen, Sigurdsson, Kong et al.: "New sequence variants associated with bone mineral density. ..." in: Nature genetics, Vol. 41, Issue 1, pp. 15-7, 2008 (PubMed).

Poulin, Nobrega, Plajzer-Frick, Holt, Afzal, Rubin, Pennacchio: "In vivo characterization of a vertebrate ultraconserved enhancer." in: Genomics, Vol. 85, Issue 6, pp. 774-81, 2005 (PubMed).

Bione, Rizzolio, Sala, Ricotti, Goegan, Manzini, Battaglia, Marozzi, Vegetti, Dalprà, Crosignani, Ginelli, Nappi, Bernabini, Bruni, Torricelli, Zuffardi, Toniolo: "Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B." in: Human reproduction (Oxford, England), Vol. 19, Issue 12, pp. 2759-66, 2004 (PubMed).