BCL2-Associated X Protein (BAX) (N-Term) Peptide
BAX
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all BAX products
- BAX (BCL2-Associated X Protein (BAX))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- IMKTGALLLQ GFIQDRAGRM GGEAPELALD PVPQDASTKK LSECLKRIGD
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-BAX Antibody(ARP58870_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- BAX (BCL2-Associated X Protein (BAX))
- Synonyms
- BAX-ALPHA Peptide, bax-A Peptide, xBax Peptide, xlbax Peptide, BAX Peptide, bax Peptide, fj16e01 Peptide, wu:fc50b10 Peptide, wu:fj16e01 Peptide, BCL2L4 Peptide, zgc:112983 Peptide, BCL2 associated X, apoptosis regulator Peptide, BCL2-associated X protein L homeolog Peptide, BCL2-associated X protein Peptide, bcl2-associated X protein, a Peptide, bcl2-associated X protein, b Peptide, BAX Peptide, bax.L Peptide, bax Peptide, baxa Peptide, Bax Peptide, baxb Peptide
- Background
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The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Alias Symbols: BCL2L4
Protein Interaction Partner: TP53,TP53,TP73,BBC3,BCL2,BCL2,BCL2L1,BCL2L1,BID,MOAP1,NOL3,BAK1,BBC3,BCL2,BCL2A1,BCL2L1,BCL2L10,BID,ERN1,KCNA3,MCL1,MOAP1,NOL3,PMAIP1,PPP1CA,SFN,SH3GLB1,SLC25A4,VDAC1,YWHAQ,GTF2B,MUC1,TAF1,TBP,TP53,BAK1,BAX,BCL2,BCL2A1,BCL2L1,BCL2L1,BCL2L10,BCL2L2,BNIPL,B
Protein Size: 218 - Molecular Weight
- 24 kDa
- Gene ID
- 581
- NCBI Accession
- NM_004324, NP_004315
- UniProt
- Q07812
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