Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2) Peptide
CBFA2T2
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
-
- Target See all CBFA2T2 products
- CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
- Origin
- Human, Mouse
-
Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CBFA2T2 antibody (Catalog #: ARP38558_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
-
-
- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))
- Synonyms
- MTGR1 Peptide, A430091M07 Peptide, C330013D05Rik Peptide, Cbfa2t2h Peptide, EHT Peptide, ZMYND3 Peptide, p85 Peptide, XETOR Peptide, cbfa2t2-a Peptide, CBFA2/RUNX1 translocation partner 2 Peptide, core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human) Peptide, CBFA2/RUNX1 translocation partner 2 L homeolog Peptide, Cbfa2t2 Peptide, CBFA2T2 Peptide, cbfa2t2.L Peptide
- Background
-
In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. CBFA2T2 binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Alias Symbols: DKFZp313F2116, EHT, MTGR1, ZMYND3, p85
Protein Interaction Partner: RUNX1T1,ATN1,CBFA2T3,CBFB,MDFI,NCOR1,NCOR2,RERE,RUNX1,SIN3A,WDYHV1,CBFA2T3,MDFI,RUNX1,RUNX1T1,TAL1,WDYHV1
Protein Size: 604 - Molecular Weight
- 67 kDa
- Gene ID
- 9139
- NCBI Accession
- NM_005093, NP_005084
- UniProt
- O43439
-
You are here:
