Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6) (C-Term) Peptide
CYP2A6
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CYP2A6 products
- CYP2A6 (Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- MEAVIHEIQR FGDVIPMSLA RRVKKDTKFR DFFLPKGTEV YPMLGSVLRD
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CYP2A6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CYP2A6 (Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 (CYP2A6))
- Synonyms
- CPA6 Peptide, CYP2A Peptide, CYP2A3 Peptide, CYPIIA6 Peptide, P450C2A Peptide, P450PB Peptide, cyp2a6 Peptide, cytochrome P450 family 2 subfamily A member 6 Peptide, cytochrome P450 2A6 Peptide, cytochrome P450 family 2 subfamily A member 6 L homeolog Peptide, CYP2A6 Peptide, cyp2a6.L Peptide
- Background
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CYP2A6 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3, however, it has been renamed CYP2A6.
Alias Symbols: CPA6, CYP2A, CYP2A3, P450C2A, P450PB, CYPIIA6
Protein Size: 494 - Molecular Weight
- 56 kDa
- Gene ID
- 1548
- NCBI Accession
- NM_000762, NP_000753
- UniProt
- P11509
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