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Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (N-Term) Peptide

HGF Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN977963
  • Target See all HGF products
    HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))
    Protein Region
    N-Term
    Origin
    Human
    Source
    • 5
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Sequence
    PFNSMSSGVK KEFGHEFDLY ENKDYIRNCI IGKGRSYKGT VSITKSGIKC
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-HGF Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))
    Synonyms
    DFNB39 Peptide, F-TCF Peptide, HGFB Peptide, HPTA Peptide, SF Peptide, HGF Peptide, C230052L06Rik Peptide, HGF/SF Peptide, NK1 Peptide, NK2 Peptide, SF/HGF Peptide, hepatocyte growth factor Peptide, HGF Peptide, Hgf Peptide
    Background
    Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69- kDa alpha-chain and 34- kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.

    Alias Symbols: HGF,HPTA,

    Protein Size: 728
    Molecular Weight
    79 kDa
    Gene ID
    3082
    NCBI Accession
    XP_006716019
    UniProt
    P14210
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