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Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA) (N-Term) Peptide

HLA-DMA Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN978020
  • Target See all HLA-DMA products
    HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
    Protein Region
    N-Term
    Origin
    Human
    Source
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Sequence
    GLSEAYDEDQ LFFFDFSQNT RVPRLPEFAD WAQEQGDAPA ILFDKEFCEW
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-HLA-DMA Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))
    Synonyms
    RT1.Ma Peptide, RT1.DMa Peptide, HLA-DMA Peptide, H-2Ma Peptide, H2-Ma Peptide, D6S222E Peptide, DMA Peptide, HLADM Peptide, RING6 Peptide, RT1 class II, locus DMa Peptide, SLA-DM alpha chain Peptide, major histocompatibility complex, class II, DM alpha Peptide, histocompatibility 2, class II, locus DMa Peptide, RT1-DMa Peptide, SLA-DMA Peptide, DLA-DMA Peptide, H2-DMa Peptide, HLA-DMA Peptide
    Background
    HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.

    Alias Symbols: D6S222E, DMA, HLADM, RING6

    Protein Interaction Partner: CD74,CD82,HLA-DMB,HLA-DOA,HLA-DRA,HLA-DRB1,HLA-DRB1

    Protein Size: 261
    Molecular Weight
    29 kDa
    Gene ID
    3108
    NCBI Accession
    NM_006120, NP_006111
    UniProt
    Q31604
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