Islet Amyloid Polypeptide (IAPP) (N-Term) Peptide

Details for Product No. ABIN978369, Supplier: Log in to see
Protein Name
  • DAP
  • IAP
  • LOC100230121
  • Amylin
  • islet amyloid polypeptide
  • IAPP
  • Iapp
Protein Region
N-Term
Origin
Human
18
9
7
2
2
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
Options
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Blocked Antibody anti-Islet Amyloid Polypeptide (IAPP) (N-Term) antibody (ABIN2776959)
Sequence MGILKLQVFL IVLSVALNHL KATPIESHQV EKRKCNTATC ATQRLANFLV
Characteristics This is a synthetic peptide designed for use in combination with anti-IAPP Antibody(ARP41728_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Purification Purified
Protein Name
Background Islet, or insulinoma, amyloid polypeptide is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Studies suggest that amylin, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.

Alias Symbols: AMYLIN, DAP, IAP

Protein Interaction Partner: COL25A1,PCSK1,PCSK2,PDX1,RAMP1,RAMP2

Protein Size: 89
Molecular Weight 4 kDa
Gene ID 3375
NCBI Accession NM_000415, NP_000406
UniProt P10997
Application Notes Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Concentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.