Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4) (Middle Region) Peptide
ID4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ID4 products
- ID4 (Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-ID4 antibody (Catalog #: ARP32327_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ID4 (Inhibitor of DNA Binding 4, Dominant Negative Helix-Loop-Helix Protein (ID4))
- Synonyms
- Idb4 Peptide, bHLHb27 Peptide, cb547 Peptide, fb77d04 Peptide, sb:cb547 Peptide, wu:fb77d04 Peptide, zgc:123214 Peptide, bhlhb27 Peptide, id4 Peptide, id4a Peptide, idb4 Peptide, IDB4 Peptide, inhibitor of DNA binding 4 Peptide, inhibitor of DNA binding 4, HLH protein Peptide, inhibitor of DNA binding 4, HLH protein S homeolog Peptide, Id4 Peptide, id4 Peptide, id4.S Peptide, ID4 Peptide
- Background
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Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins.Transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins (Pagliuca et al., 1995 [PubMed 7665172]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: IDB4, bHLHb27
Protein Interaction Partner: HES1,ID3,MYOD1,TCF4
Protein Size: 161 - Molecular Weight
- 16 kDa
- Gene ID
- 3400
- NCBI Accession
- NM_001546, NP_001537
- UniProt
- P47928
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