Interleukin 4 (IL4) (Middle Region) Peptide
IL4
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all IL-4 (IL4) products
- IL-4 (IL4) (Interleukin 4 (IL4))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-IL4 antibody (Catalog #: ARP54330_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- IL-4 (IL4) (Interleukin 4 (IL4))
- Synonyms
- IL4 Peptide, IL-4 Peptide, BCGF-1 Peptide, BCGF1 Peptide, BSF-1 Peptide, BSF1 Peptide, Il-4 Peptide, Il4e12 Peptide, IL2 Peptide, interleukin 4 Peptide, IL4 Peptide, Il4 Peptide
- Background
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IL4 participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Alias Symbols: BSF1, IL-4, MGC79402, BCGF1, BSF-1, BCGF-1
Protein Interaction Partner: IL2RG,IL4R,IL4R,CD53,IL13RA2,IL2RG,IL4R,PIK3CD,A2M,IL4R
Protein Size: 153 - Molecular Weight
- 15 kDa
- Gene ID
- 3565
- NCBI Accession
- NM_000589, NP_000580
- UniProt
- P05112
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