Klotho beta (KLB) Peptide
KLB
Reactivity: Human
Host: Synthetic
BP, IHC, WB
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- Target See all Klotho beta (KLB) products
- Klotho beta (KLB)
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-KLB antibody (Catalog #: ARP53325_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Klotho beta (KLB)
- Synonyms
- KLB Peptide, BKL Peptide, AV071179 Peptide, betaKlotho Peptide, Klb-ps1 Peptide, RGD1308227 Peptide, klotho beta Peptide, KLB Peptide, Klb Peptide
- Background
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KLB is a single-pass type III membrane protein. It contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. KLB is probably inactive as a glycosidase. It increases the ability of FGFR1 and FGFR4 to bind FGF21.
Alias Symbols: BKL, MGC142213
Protein Interaction Partner: FGF21
Protein Size: 1044 - Molecular Weight
- 120 kDa
- Gene ID
- 152831
- NCBI Accession
- NM_175737, NP_783864
- UniProt
- Q86Z14
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