E3 ubiquitin-protein ligase NEDD4-like (NEDD4L) (Middle Region) Peptide
NEDD4L
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all NEDD4-2 (NEDD4L) products
- NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-NEDD4L antibody (Catalog #: ARP43192_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NEDD4-2 (NEDD4L) (E3 ubiquitin-protein ligase NEDD4-like (NEDD4L))
- Synonyms
- NEDD4-2 Peptide, NEDD4.2 Peptide, RSP5 Peptide, hNEDD4-2 Peptide, nedd4 Peptide, nedd4-2 Peptide, NEDD4 Peptide, Nedd4-2 Peptide, 1300012C07Rik Peptide, Nedd4b Peptide, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase Peptide, NEDD4L Peptide, neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase S homeolog Peptide, neural precursor cell expressed, developmentally down-regulated gene 4-like Peptide, NEDD4L Peptide, LOC776799 Peptide, nedd4l.S Peptide, Nedd4l Peptide
- Background
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NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.
Alias Symbols: FLJ33870, KIAA0439, RSP5, hNedd4-2, NEDD4-2, NEDD4.2, hNEDD4-2
Protein Interaction Partner: HHV4gp002,ARHGDIA,LAPTM5,NDFIP2,NTRK1,RNF11,SCN5A,SCNN1A,SCNN1B,SCNN1G,SGK1,UBE2E1,UBE2L3,AMOT,ARHGDIA,NEDD4L,NR3C1,SCNN1A,SCNN1B,SCNN1G,SFN,UBA1,UBC
Protein Size: 955 - Molecular Weight
- 110 kDa
- Gene ID
- 23327
- NCBI Accession
- NM_015277, NP_056092
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