Numb Homolog (NUMB) (C-Term) Peptide
NUMB
Reactivity: Human, Mouse
Host: Synthetic
BP, WB, IHC
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- Target See all NUMB products
- NUMB (Numb Homolog (NUMB))
- Protein Region
- C-Term
- Origin
- Human, Mouse
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- ASGNRHAEVP PGTCPVDPFE AQWAALESKS KQRTNPSPTN PFSSDLQKTF
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Numb Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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Numb Homolog (NUMB) peptide
NUMB Reactivity: Human, Mouse, Cow, Dog Host: Synthetic BP, Imm
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- NUMB (Numb Homolog (NUMB))
- Synonyms
- C14orf41 Peptide, S171 Peptide, c14_5527 Peptide, Nb Peptide, NUMB, endocytic adaptor protein Peptide, numb homolog (Drosophila) Peptide, NUMB Peptide, Numb Peptide, numb Peptide
- Background
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Numb plays a role in the process of neurogenesis. It is required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. It is not required for the proliferation of neural progenitor cells before the onset of neurogenesis. It is also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. It may also mediate local repair of brain ventricular wall damage.
Alias Symbols: m-numb, mnb, m-Nb
Protein Interaction Partner: Lnx2,Lnx1,Ehd1,Ehd4,Lnx1,Eps15
Protein Size: 604 - Molecular Weight
- 66 kDa
- Gene ID
- 18222
- NCBI Accession
- NM_010949, NP_035079
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