Protein Inhibitor of Activated STAT, 3 (PIAS3) (Middle Region) Peptide
PIAS3
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PIAS3 products
- PIAS3 (Protein Inhibitor of Activated STAT, 3 (PIAS3))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PIAS3 antibody (Catalog #: ARP32763_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PIAS3 (Protein Inhibitor of Activated STAT, 3 (PIAS3))
- Synonyms
- PIAS3 Peptide, Pias3l Peptide, ZMIZ5 Peptide, protein inhibitor of activated STAT 3 Peptide, protein inhibitor of activated STAT, 3 Peptide, protein inhibitor of activated STAT 3 L homeolog Peptide, PIAS3 Peptide, pias3 Peptide, Pias3 Peptide, pias3.L Peptide
- Background
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PIAS3 is a member of the protein inhibitor of activated STAT (PIAS) family. It also activates TGF-beta/SMAD transcriptional responses. This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ14651, ZMIZ5
Protein Interaction Partner: GEMIN4,ZFHX3,AR,ATF7IP,EP300,ESR1,ESR2,GEMIN4,GFI1,HABP4,HDAC1,HMGA2,MITF,NCOA2,NR3C2,OPN1LW,PGR,PRPF40A,RELA,SERBP1,SKIL,SMAD2,SMAD3,SMAD4,STAT3,TBP,ZFHX3,AR,CREBBP,EP300,GFI1,HMGA2,MITF,RELA,SIAH1,SIAH2,SMAD2,SMAD3,SMAD4,STAT3,TRIM32,UBC,ZMIZ1,ZMIZ2
Protein Size: 628 - Molecular Weight
- 68 kDa
- Gene ID
- 10401
- NCBI Accession
- NM_006099, NP_006090
- UniProt
- Q9Y6X2
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