Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) (C-Term) Peptide
PICALM
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all PICALM products
- PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- DLDSSLANLV GNLGIGNGTT KNDVNWSQPG EKKLTGGSNW QPKVAPTTAW
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PICALM Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))
- Synonyms
- LAP-3 Peptide, PEPS Peptide, CALM Peptide, CLTH Peptide, LAP Peptide, PAP180 Peptide, fit-1 Peptide, fit1 Peptide, mKIAA4114 Peptide, Calm Peptide, leucine aminopeptidase 3 Peptide, phosphatidylinositol binding clathrin assembly protein Peptide, si:ch211-200p22.4 Peptide, LAP3 Peptide, PICALM Peptide, Picalm Peptide, si:ch211-200p22.4 Peptide
- Background
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This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10,11)(p13,q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease.
Alias Symbols: CALM, CLTH, LAP
Protein Interaction Partner: AP2A1,CASP3,CASP8,CLTC,CLTCL1,DDIT3,EHD2,PLCG1,CLTC,DDIT3,PLCG1
Protein Size: 551 - Molecular Weight
- 60 kDa
- Gene ID
- 8301
- NCBI Accession
- NM_001206947, NP_001193876
- UniProt
- E9PN05
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