Perforin 1 (Pore Forming Protein) (PRF1) Peptide
PRF1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all Perforin 1 (PRF1) products
- Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PRF1 antibody (Catalog #: ARP42208_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
- Synonyms
- FLH2 Peptide, HPLH2 Peptide, P1 Peptide, PFN1 Peptide, PFP Peptide, PRF1 Peptide, Pfn Peptide, Pfp Peptide, Prf-1 Peptide, Cyta Peptide, RATCYTA Peptide, LOC443187 Peptide, perforin Peptide, prf1 Peptide, cytolysin Peptide, perforin-1 Peptide, perforin-1-like Peptide, perforin 1 Peptide, perforin 1 (pore forming protein) Peptide, perforin Peptide, perforin 1 L homeolog Peptide, PRF1 Peptide, Prf1 Peptide, LOC443187 Peptide, prf1 Peptide, prf1.L Peptide
- Background
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PRF1 has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the gene encoding PRF1 cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: FLH2, HPLH2, MGC65093, P1, PFP, PFN1
Protein Interaction Partner: CALR,DDX24,GZMB,CALR
Protein Size: 555 - Molecular Weight
- 59 kDa
- Gene ID
- 5551
- NCBI Accession
- NM_005041, NP_005032
- UniProt
- P14222
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