Spindle and Kinetochore Associated Complex Subunit 1 (SKA1) (Middle Region) Peptide
SKA1
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
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- Target See all SKA1 products
- SKA1 (Spindle and Kinetochore Associated Complex Subunit 1 (SKA1))
- Protein Region
- Middle Region
- Origin
- Human, Mouse
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- LLNKFELEIQ YQEQTNSSLK ELCESLREEC EDVEHLKEHV PPHLPQVTAT
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-Ska1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SKA1 (Spindle and Kinetochore Associated Complex Subunit 1 (SKA1))
- Synonyms
- C18H18orf24 Peptide, C18orf24 Peptide, 2810433K01Rik Peptide, AV117428 Peptide, RGD1310784 Peptide, spindle and kinetochore associated complex subunit 1 Peptide, SKA1 Peptide, ska1 Peptide, Ska1 Peptide
- Background
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Ska1 is a Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. It is required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules.
Alias Symbols: 2810433K01Rik, AV117428
Protein Size: 254 - Molecular Weight
- 28 kDa
- Gene ID
- 66468
- NCBI Accession
- NM_025581, NP_079857
- UniProt
- Q9CPV1
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