Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box) (TCF7L1) (N-Term) Peptide
TCF7L1
Reactivity: Human
Host: Synthetic
BP, WB, IHC
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- Target See all TCF7L1 products
- TCF7L1 (Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box) (TCF7L1))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-TCF7L1 antibody (Catalog #: ARP30092_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TCF7L1 (Transcription Factor 7-Like 1 (T-Cell Specific, HMG-Box) (TCF7L1))
- Synonyms
- TCF-3 Peptide, TCF3 Peptide, Tcf-3 Peptide, Tcf3 Peptide, bHLHb21 Peptide, tcf3c Peptide, tcf3d Peptide, xtcf3 Peptide, XTCF-3 Peptide, tcf7l1 Peptide, tcf3b Peptide, TCF-3-A Peptide, tcf-3 Peptide, tcf3 Peptide, tcf3a Peptide, zTcf-3 Peptide, transcription factor 7 like 1 Peptide, transcription factor 7 like 1 (T cell specific, HMG box) Peptide, transcription factor 7 like 1 L homeolog Peptide, transcription factor 7 like 1 S homeolog Peptide, transcription factor 7 like 1b Peptide, transcription factor 7 like 1a Peptide, TCF7L1 Peptide, Tcf7l1 Peptide, tcf7l1.L Peptide, tcf7l1.S Peptide, tcf7l1b Peptide, tcf7l1a Peptide
- Background
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TCF7L1 participates in the Wnt signaling pathway. It binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. It is necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. TCF7L1 down-regulates NQO1, leading to increased mitomycin c resistance.
Alias Symbols: TCF-3, TCF3
Protein Interaction Partner: CTNNB1,CTNNB1
Protein Size: 588 - Molecular Weight
- 63 kDa
- Gene ID
- 83439
- NCBI Accession
- NM_031283, NP_112573
- UniProt
- Q9HCS4
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