UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B) (Middle Region) Peptide
UPF3B
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all UPF3B products
- UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-UPF3B antibody (Catalog #: ARP41088_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- UPF3B (UPF3 Regulator of Nonsense Transcripts Homolog B (UPF3B))
- Synonyms
- HUPF3B Peptide, MRXS14 Peptide, RENT3B Peptide, UPF3X Peptide, 5730594O13Rik Peptide, AI317193 Peptide, AW541158 Peptide, RGD1560264 Peptide, UPF3B, regulator of nonsense mediated mRNA decay Peptide, UPF3 regulator of nonsense transcripts homolog B (yeast) Peptide, UPF3B Peptide, Upf3b Peptide
- Background
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UPF3B is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The protein is one of two functional homologs to yeast Upf3p. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.
Alias Symbols: HUPF3B, MRXS14, RENT3B, UPF3X
Protein Interaction Partner: EIF6,EXOSC4,MCRS1,RBM8A,TTC19,UPF1,UPF2,UPF3B,XRN1,EIF6,HBB,MCRS1,TTC19,UPF1,UPF1,UPF2,UPF3A,USP21
Protein Size: 483 - Molecular Weight
- 58 kDa
- Gene ID
- 65109
- NCBI Accession
- NM_080632, NP_542199
- UniProt
- Q9BZI7
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