(1 reference)-
- Target See all beta Amyloid (Abeta) products
- beta Amyloid (Abeta) (Amyloid beta (Abeta))
- Protein Region
- AA 1-40
- Sequence
- One-letter code: DAEFRHDSGY EVHHQKLVFF AEDVGSNKGA IIGLMVGGV, Three-letter code: {ASP}{ALA}{GLU}{PHE}{ARG}{HIS}{ASP}{SER}{GLY}{TYR}{GLU}{VAL}{HIS}{HIS}{GLN}{LYS}{LEU}{VAL}{PHE}{PHE}{ALA}{GLU}{ASP} {VAL}{GLY}{SER}{ASN}{LYS}{GLY}{ALA}{ILE}{ILE}{GLY}{LEU}{MET}{VAL}{GLY}{GLY}{VAL}{VAL
- Characteristics
- Formula: C194H295N53O58S1
- Purity
- > 95 %
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- Comment
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Note: In culture, beta-amyloid peptide is neurotrophic to undifferentiated hippocampal neurons at low. Concentrations and neurotoxic to mature neurons at higher Concentrations. In differentiated neurons, it causes dendritic and axonal retraction followed by neuronal death.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Storage
- -20 °C
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-
: "Retardation of Abeta fibril formation by phospholipid vesicles depends on membrane phase behavior." in: Biophysical journal, Vol. 98, Issue 10, pp. 2206-14, (2010) (PubMed).
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: "Retardation of Abeta fibril formation by phospholipid vesicles depends on membrane phase behavior." in: Biophysical journal, Vol. 98, Issue 10, pp. 2206-14, (2010) (PubMed).
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- Target
- beta Amyloid (Abeta) (Amyloid beta (Abeta))
- Synonyms
- AAA Peptide, ABETA Peptide, ABPP Peptide, AD1 Peptide, APPI Peptide, CTFgamma Peptide, CVAP Peptide, PN-II Peptide, PN2 Peptide, aaa Peptide, abeta Peptide, abpp Peptide, ad1 Peptide, appi Peptide, ctfgamma Peptide, cvap Peptide, pn2 Peptide, Abeta Peptide, Abpp Peptide, Adap Peptide, Ag Peptide, Cvap Peptide, E030013M08Rik Peptide, betaApp Peptide, amyloid beta precursor protein Peptide, amyloid beta (A4) precursor protein Peptide, APP Peptide, app Peptide, App Peptide
- Background
- Beta-amyloid peptide (beta-APP) is a 40-residue peptide implicated in the pathogenesis of Alzheimers disease (AD) and aged Down's Syndrome, which is promoted by the acquisition of an additional copy of chromosome 21. The peptide is a proteolytic product of the much larger amyloid precursor protein (APP) encoded by a gene on chromosome 21. The peptide comprises a large extracellular N-terminal domain and a short hydrophobic membrane-spanning domain, followed by a short C-terminal region. Beta-APP both precedes and forms part of the transmembrane region. Synonym: amyloid peptide, amyloid beta protein, beta amyloid plaques. Solubility: Insoluble in water, may be dissolved in any buffer of pH >9.
- Molecular Weight
- 4329.82
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