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Human Monoclonal BHLHE40 Primary Antibody for ELISA, WB - ABIN563685
Lecomte, Meugnier, Euthine, Durand, Freyssenet, Nemoz, Rome, Vidal, Lefai: A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation. in Molecular and cellular biology 2010
Show all 2 Pubmed References
Human Polyclonal BHLHE40 Primary Antibody for WB - ABIN654604
Wang, Reiser-Erkan, Michalski, Raggi, Quan, Yupei, Friess, Erkan, Kleeff: Hypoxia inducible BHLHB2 is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. in Biochemical and biophysical research communications 2010
Show all 2 Pubmed References
DEC1 is involved in hypoxia-induced EMT (show ITK Antibodies) processes via negatively regulating E-cadherin (show CDH1 Antibodies) expression in HepG2 cells.
This study was performed to test the hypothesis that the SHP (show LAMC1 Antibodies) gene is a target gene of DEC1. Cotransfection demonstrated that DEC1 repressed the SHP (show LAMC1 Antibodies) promoter and attenuated the transactivation of the classic circadian activator complex of Clock/Bmal1 (show ARNTL Antibodies).
Dec1 is a prognostic factor for the clinical outcome and a predictive factor for the response to TMZ chemotherapy in patients with glioma
decreases of CES and CYP3A4 (show CYP3A4 Antibodies) expression and enzymatic activities induced by Fluoxetine are through decreasing PXR (show NR1I2 Antibodies) and increasing DEC1 in HepG2 cells
Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 (show ASS1 Antibodies) is regulated by DEC1, HIF-1alpha (show HIF1A Antibodies), and c-Myc (show MYC Antibodies) transcription network and is independent of ASS1 (show ASS1 Antibodies) promoter DNA methylation (show HELLS Antibodies).
High BHLHE40 expression is associated with glioblastomas.
STRA13 may be essential for the progression of atopic dermatitis by interacting with hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-148b and hsamiR- 152.
BHLHE40 was identified as a viable candidate for which a droplet digital PCR assay for demethylation was developed. The assay revealed high demethylation in activated NK cells and low demethylation in naive NK, T- and B-cells. We conclude the NK cell methylome is plastic with potential for remodeling.
findings suggested that posttranslational modification of DEC1 in the form of SUMOylation may serve as a key factor that regulates the function of DEC1 in vivo
Study conclude that DeltaNp63 is a novel target of DEC1 and HDAC2 (show HDAC2 Antibodies) and modulates the efficacy of HDAC (show HDAC3 Antibodies) inhibitors in growth suppression and keratinocyte differentiation.
Expression of DEC1 is evolutionally conserved in zebrafish.
This study aimed to lay the groundwork to further study of Bhlhe40 function at myogenesis and adipogenesis in bovine and should significantly contribute to cattle breeding and genetics through MAS (show MAS1 Antibodies) program
Loss of Bhlhe40 expression is associated with impaired long term potentiation and long term depression at CA1 (show CA1 Antibodies) synapses.
This study demonstrates that downregulation of DEC1 contributes to MPP(+) -induced neurotoxicity by suppressing PI3K/Akt/GSK3beta pathway.
These results indicate that Bhlhe40 works as a cofactor of T-bet for enhancing IFN-gamma (show IFNG Antibodies) production in iNKT cells.
Bhlhe40 expression identifies encephalitogenic Th cells and defines a PTX-IL-1 (show IL1A Antibodies)-Bhlhe40 pathway active in experimental autoimmune encephalomyelitis.
Collectively, the data obtained in this study suggest that DEC1 is a novel negative regulator of hepatic FGF21 (show FGF21 Antibodies) expression
establishes a crucial role of Bhlhe40 in mediating the repressive effect of hypoxia on myogenic differentiation and suggests that inhibition of Bhlhe40 or p53 (show TP53 Antibodies) may facilitate muscle regeneration after ischemic injuries
There was an inverse relationship between DEC1 expression and AMPK (show PRKAA1 Antibodies) activity. Our results suggest that DEC1 negatively regulates AMPK (show PRKAA1 Antibodies) activity via LKB1 (show STK11 Antibodies)
Data show that the bHLH transcription factors SHARP1 and SHARP2 are involved in cognitive processing by controlling insulin-like growth factor II (Igf2) expression and associated signaling cascades.
Data indicate that bHLH transcription factors Bhlhe40 interacts with PGC-1alpha protein (PGC-1alpha) and represses its transcriptional activity.
abnormal sleep and certain (endo)phenotypes of psychiatric diseases may be caused by common mechanisms involving components of the molecular clock including SHARP1 (show BHLHE41 Antibodies) and SHARP2.
This gene encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. The encoded protein is believed to be involved in the control of cell differentiation.
basic helix-loop-helix domain containing, class B, 2
, class B basic helix-loop-helix protein 2
, class E basic helix-loop-helix protein 40
, differentially expressed in chondrocytes 1
, differentially expressed in chondrocytes protein 1
, differentiated embryo chondrocyte expressed gene 1
, enhancer-of-split and hairy-related protein 2
, stimulated by retinoic acid gene 13 protein
, bHLH protein DEC1
, Class B basic helix-loop-helix protein 2
, basic helix-loop-helix domain containing class B2 protein
, basic helix-loop-helix family, member e40
, class E basic helix-loop-helix protein 40-like
, E47 interaction protein 1
, basic helix-loop-helix domain containing, class B2
, cytokine response gene 8
, eip1 (E47 interaction protein 1)
, enhancer-of split and hairy-related protein 2
, stimulated by retinoic acid 14