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Authors demonstrate that mtp53 prevents the COP1 (show CARD16 ELISA Kits)/DET1 complex from ubiquitinating ETS2 (show ETS2 ELISA Kits) and thereby marking it for destruction. Authors show that mtp53 destabilizes DET1 and also disrupts the DET1/ETS2 (show ETS2 ELISA Kits) complex thereby preventing ETS2 (show ETS2 ELISA Kits) degradation.
STK40 (show STK40 ELISA Kits) binds the COP1 (show CARD16 ELISA Kits) WD40 domain (show DCAF12L2 ELISA Kits) using a VPD/E motif in its C-terminal tail.
In conclusion, miR (show MLXIP ELISA Kits)-214 functions as a tumor suppressor by regulating the RFWD2-p53 (show TP53 ELISA Kits) cascade, thus delivery of miR (show MLXIP ELISA Kits)-214 analogs could be a potential adjunct therapy in breast cancer harboring wild type p53 (show TP53 ELISA Kits).
the reduced expression of COP1 (show CARD16 ELISA Kits) and the upregulated expression of ETV1 (show ETV1 ELISA Kits) in RCC (show XRCC1 ELISA Kits) tissue samples, which was associated with a high tumor-node-metastasis stage of RCC (show XRCC1 ELISA Kits). Furthermore, the overexpression of COP1 (show CARD16 ELISA Kits) in the RCC (show XRCC1 ELISA Kits) ACHN cells inhibited the migration and invasion of ACHN cells, and downregulated ETV1 (show ETV1 ELISA Kits) and MMP7 (show MMP7 ELISA Kits) expression levels.
COP1 (show CARD16 ELISA Kits) expression was an independent predictor of overall survival.
the present study revealed that COP1 (show CARD16 ELISA Kits) plays an important role in CLL cell proliferation and tumorigenicity, and may be a useful indicator of the chronic lymphocytic leukemia processes.
COP1 (show CARD16 ELISA Kits) directly interacts with p27 (show PAK2 ELISA Kits) through a VP motif on p27 (show PAK2 ELISA Kits) and functions as an E3 ligase of p27 (show PAK2 ELISA Kits) to accelerate the ubiquitin-mediated degradation of p27 (show PAK2 ELISA Kits). COP1 (show CARD16 ELISA Kits)-p27 (show PAK2 ELISA Kits) axis deregulation is involved in tumorigenesis.
COP1 (show CARD16 ELISA Kits) overexpression leads to the cytoplasmic distribution of p27 (show PAK2 ELISA Kits), thereby accelerating p27 (show PAK2 ELISA Kits) degradation.
COP1 (show CARD16 ELISA Kits) negatively regulates ETV1 (show ETV1 ELISA Kits) in patients with triple-negative breast cancer.
TRIB2 (show TRIB2 ELISA Kits) associated-ubiquitin E3 ligases beta-transducin repeat-containing E3 ubiquitin protein ligase (beta-TrCP (show BTRC ELISA Kits)), COP1 (show CARD16 ELISA Kits) and Smad ubiquitination regulatory factor 1 (Smurf1 (show SMURF1 ELISA Kits)) reduced TCF4 (show TCF4 ELISA Kits)/beta-Catenin (show CTNNB1 ELISA Kits) expression, and these effects could be enhanced by TRIB2 (show TRIB2 ELISA Kits).
Prenatal inactivation of Rfwd2 gene in the lung epithelium led to a striking halt in branching morphogenesis shortly after secondary branch formation.
Study shows that post-translational regulation of the transcription factors ETV1, ETV4, and ETV5 by the ubiquitin ligase COP1 (also called RFWD2) in beta cells is critical for insulin secretion. Mice lacking COP1 in beta cells developed diabetes due to insulin granule docking defects that were fully rescued by genetic deletion of Etv1, Etv4, and Etv5.
These results indicate that COP1 and Trib1 (show TRIB1 ELISA Kits) act as an oncoprotein complex functioning upstream of C/EBPalpha (show CEBPA ELISA Kits), and its ligase activity is crucial for leukemogenesis.
COP1 physically interacted with PTP1B (show PTPN1 ELISA Kits) and suppressed PTP1B (show PTPN1 ELISA Kits) phosphatase activity as well as the association of PTP1B (show PTPN1 ELISA Kits) with IRbeta.
Modulation of fatty acid synthase (show FASN ELISA Kits) degradation by concerted action of p38 MAP kinase (show MAPK14 ELISA Kits), E3 ligase COP1, and SH2-tyrosine phosphatase Shp2 (show PTPN11 ELISA Kits).
the ubiquitin ligase (show RNF123 ELISA Kits) COP1 (also known as RFWD2) is a tumour suppressor that negatively regulates ETV1 (show ETV1 ELISA Kits), ETV4 (show ETV4 ELISA Kits) and ETV5; ETV1 (show ETV1 ELISA Kits), which is mutated in prostate cancer more often, was degraded after being ubiquitinated by COP1
Cop1 is a tumor suppressor that functions, at least in part, by antagonizing c-Jun (show JUN ELISA Kits) oncogenic activity.
Rfwd2 is associated with acute lung injury
description of a pathway in which Tribbles 3 (TRB3 (show TRIB3 ELISA Kits)) stimulates lipolysis by triggering the degradation of acetyl-coenzyme A carboxylase (ACC (show ACACA ELISA Kits)) in adipose tissue; TRB3 (show TRIB3 ELISA Kits) promoted ACC (show ACACA ELISA Kits) ubiquitination through an association with the E3 ubiquitin ligase COP1
Disruption of the COP1-mediated proteolysis by ionizing radiation leads to MTA1 (show MTA1 ELISA Kits) stabilization.
Data indicate localization of UVR8 signaling in the nucleus and a dual role for COP1 in the regulation of UV-B-induced UVR8 nuclear accumulation and in UVR8-mediated UV-B signaling.
COP1 promotes the degradation of HFR1 under shade, thus increasing the ability of PIFs (show PROC ELISA Kits) to control gene expression, increase auxin levels and promote stem growth.
SPA (show FASL ELISA Kits) proteins have a dual role: (1) they are required for light-responsiveness of COP1 subcellular localization, and (2) they promote COP1 activity in darkness in a fashion that is independent of the nuclear import/nuclear retention of COP1.
The alpha2-cop mutant displayed defects in plant growth, including small rosettes, stems and roots and mislocalization of p24delta5, a protein of the p24 family containing a C-terminal dilysine motif involved in COPI binding. The alpha2-cop mutant also exhibited abnormal morphology of the Golgi apparatus.
Exposure to blue light is required for an in vivo-association of CRY1 (show CRY1 ELISA Kits) and CRY2 (show CRY2 ELISA Kits) with COP1.
DHU1 negatively regulates UV-B signaling via its direct interaction with COP1 and RUP1 (show SCGB1A1 ELISA Kits) (At5g52250).
BBX21 is a pivotal component involved in the COP1-HY5 regulatory hub.
Meanwhile, transcript levels of ABA biosynthesis genes are higher in cip1 (show CDKN1A ELISA Kits)-1 than in the wild-type. These results suggested that CIP1 (show CDKN1A ELISA Kits) is positively involved in ABA response.
salt stress and ethylene antagonistically regulate nucleocytoplasmic partitioning of COP1.
Our genetic and biochemical studies identify a function for SIZ1 in photomorphogenesis and reveal a novel SUMO-regulated ubiquitin ligase, COP1, in plants.
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1 (By similarity).
E3 ubiquitin-protein ligase RFWD2
, RING finger and WD repeat domain protein 2
, RING finger protein 200
, constitutive photomorphogenesis protein 1 homolog
, constitutive photomorphogenic protein (COP1)
, putative ubiquitin ligase COP1
, constitutive photomorphogenic protein 1
, ring finger and WD repeat domain 2