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Submit your validation data for this product and get a full refund. I want to validate this productRelevance Score | ABIN | Application | Conjugate | Host | Isotype | Epitope | Supplier | Clonality | References | Details |
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12.96781 | ABIN2792145 | IHC WB | Rabbit | N-Term | Log in to see | Polyclonal | 1 | |||
12.96781 | ABIN2704466 | IC IF IHC WB | Rabbit | C-Term | Log in to see | Polyclonal | 0 | |||
9.96781 | ABIN2957855 | IHC WB | Rabbit | C-Term, pSer474 | Log in to see | Polyclonal | 0 | |||
1 | ABIN2615477 | ICC IF IHC IHC (p) WB | Rabbit | C-Term | Log in to see | Polyclonal | 0 | |||
1 | ABIN2994519 | IF/ICC IHC WB | Rabbit | Log in to see | Polyclonal | 0 |
General |
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Antigen | V-Akt Murine Thymoma Viral Oncogene Homolog 2 (AKT2) Antibodies |
Epitope | Middle Region Alternatives |
Reactivity | Cow (Bovine), Dog (Canine), Horse (Equine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Zebrafish (Danio rerio) Alternatives |
Host | Rabbit Alternatives |
Clonality | |
Conjugate | This AKT2 antibody is un-conjugated Alternatives |
Application |
Immunohistochemistry (IHC), Western Blotting (WB)
Alternatives
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1 reference available |
Supplier | Log in to see |
Product Details anti-AKT2 AntibodyTarget Details AKT2 Application Details Handling References for anti-AKT2 antibody (ABIN2779323) Images |
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Blocking Peptide | Blocking peptide for this product available: ABIN973084 |
Sequence | TSEVDTRYFD DEFTAQSITI TPPDRYDSLG LLELDQRTHF PQFSYSASIR |
Predicted Reactivity | Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rat: 100%, Zebrafish: 100% |
Characteristics | This is a rabbit polyclonal antibody against AKT2. It was validated on Western Blot using a cell lysate as a positive control. |
Purification | Affinity Purified |
Immunogen | The immunogen is a synthetic peptide directed towards the middle region of human AKT2 |
Plasmids, Primers & others | |
Target Details AKT2Product Details anti-AKT2 Antibody Application Details Handling References for anti-AKT2 antibody (ABIN2779323) Images back to top |
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Antigen | |
Alternative Name | AKT2 (AKT2 Antibody Abstract) |
Background |
AKT2 belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene encoding AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT2 is a general protein kinase capable of phophorylating several known proteins.This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. Alias Symbols: PKBBETA, PRKBB, RAC-BETA, PKBB, HIHGHH Protein Interaction Partner: CLIP3, CHUK, PLEKHO1, PRKCZ, UBC, EGFR, POLR1B, SNX27, PNPLA3, STEAP4, ABCG8, POFUT1, TMED2, NAMPT, SORBS2, SPRR2A, CCL14, PRKDC, MAP3K5, HSP90AA1, APOB, APOA1, APPL1, APP, FSHR, VIM, SKI, GRK5, SH3RF1, ESR1, TTC3, SETDB1, XIAP, AKT1S1, TRIB3, PDPK1, GSK3 Protein Size: 481 |
Molecular Weight | 56 kDa |
Gene ID | 208 |
NCBI Accession | NM_001626, NP_001617 |
UniProt | P31751 |
Pathways | PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, TLR Signaling, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Hepatitis C, VEGF Signaling |
Application DetailsProduct Details anti-AKT2 Antibody Target Details AKT2 Handling References for anti-AKT2 antibody (ABIN2779323) Images back to top |
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Application Notes | Optimal working dilutions should be determined experimentally by the investigator. |
Comment |
Antigen size: 481 AA |
Restrictions | For Research Use only |
HandlingProduct Details anti-AKT2 Antibody Target Details AKT2 Application Details References for anti-AKT2 antibody (ABIN2779323) Images back to top |
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Format | Liquid |
Concentration | Lot specific |
Buffer | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose. |
Preservative | Sodium azide |
Precaution of Use | This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
Handling Advice | Avoid repeated freeze-thaw cycles. |
Storage | -20 °C |
Storage Comment | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
References for anti-AKT2 antibody (ABIN2779323)Product Details anti-AKT2 Antibody Target Details AKT2 Application Details Handling Images back to top |
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Product cited in: |
Tan, Timakhov, Rao, Altomare, Xu, Liu, Gao, Jhanwar, Di Cristofano, Wiest, Knepper, Testa: "A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice." in: Cancer research, Vol. 68, Issue 5, pp. 1296-302, 2008 |
ImagesProduct Details anti-AKT2 Antibody Target Details AKT2 Application Details Handling References for anti-AKT2 antibody (ABIN2779323) back to top |
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Supplier Images |
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