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anti-Human DEPTOR Antibodies:
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Human Polyclonal DEPTOR Primary Antibody for ICC, IF - ABIN4304935
Jegg, Ward, Iorns, Hoe, Zhou, Liu, Singh, Landgraf, Pegram: PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2+ breast cancer cells. in Breast cancer research and treatment 2012
Show all 9 Pubmed References
Human Polyclonal DEPTOR Primary Antibody for IF (p), IHC (p) - ABIN1387597
Liu, Zhang, Liu, Li, Zhang, Li, Liu, Huang, Shen, Gu, Gao, Wu, Wu: High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma. in OncoTargets and therapy 2015
The dysregulation of SIRT1-DEPTOR-mTORC1 signaling is a critical determinant of alcoholic liver disease pathology; targeting SIRT1 and DEPTOR and selectively inhibiting mTORC1-S6K1 signaling may have therapeutic potential for treating alcoholic liver disease in humans
key modulator that plays important roles in fine tuning the activity of mTOR and the activation state of the PI3K-AKT axis, with a deep impact on cancer, metabolism, and immunity [review]
Using computational modeling, systems analysis and dynamic simulations, study shows that DEPTOR confers remarkably rich and complex dynamic behaviours to mTOR signalling, including abrupt, bistable switches, oscillations and co-existing bistable/oscillatory responses. Transitions between these distinct modes of behavior are enabled by modulating DEPTOR expression alone.
In ASS1-knockout cells, DEPTOR, an inhibitor of mTORC1 signal, was downregulated and mTORC1 signaling was more activated in response to arginine.
Deptor depletion induces endoplasmic reticulum (ER) stress and synergizes the effect of the proteasome inhibitor bortezomib (Bz) in multiple myeloma (MM) cells.
DEPTOR overexpression is associated with cervical squamous cell carcinoma.
Studies provide evidence that Deptor appears to play an important role in the pathogenesis of many types of cancers, mainly through its role in controlling the activity of mTOR and many other possible functions. [review]
Low DEPTOR expression is associated with esophageal squamous cell carcinoma.
Association between insulin sensitivity and genetic variants in DEPTOR gene suggest DEPTOR and mammalian target of rapamycin signaling pathway to be potential target for future research and pharmacological interventions.
High DEPTOR expression is associated with T-cell leukemia.
Results provide evidence that DEPTOR acts as a tumor suppressor by limiting EGFR-driven lung adenocarcinoma progression.
that DEPTOR expression is required to maintain myeloma cell differentiation and high level of its expression are associated with better outcome.
High expression of DEPTOR benefits esophageal squamous cell carcinoma patients in early stage but not advanced stage.
the present findings supported the fact that DEPTOR-mTOR signaling is a central regulator of lipid metabolism-mediated inflammation in lymphocytes of PBMC culture.
In this study we began by validating the expression of four main mTOR pathway components, mTOR, DEPTOR, rictor and raptor, at gene and protein level in in vitro models of endometrioid (MDAH2774) and clear cell (SKOV3) ovarian cancer
Cul1 promoted mTORC1 activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR.
Propose regulation of placental SNAT2/LAT1 ubiquitination by mTORC1 and Nedd4-2.
Deptor enhances triple-negative breast cancer metastasis and chemoresistance through coupling to survivin expression
Data suggest that DEPTOR has a tumor suppressive activity against pancreatic cancer cells, and its loss of expression may contribute to pancreatic tumorigenesis.
Data indicate that phosphatidic acid (PA) specifically disrupts DEPTOR-mTORC1 interaction.
Study revealed a novel function of DEPTOR in osteogenic differentiation by inhibiting MEG3-mediated activation of BMP4 signaling, which suggested that DEPTOR could be a therapeutic target for bone loss diseases and skeletal tissue regeneration.
Hepatic DEPTOR accelerates the inhibition of mTORC1 during the transition to fasting to adjust metabolism to the nutritional status.
Cul-1 deneddylation led to Deptor accumulation and subsequent mTOR inactivation, which had an inhibitory effect on dendritic cells in mouse model of inflammatory bowel disease.
These results support the idea that other neuronal populations are responsible for these phenotypes. Nonetheless, we observed a mild elevation in fasting blood glucose, insulin resistance, and alterations in liver glucose and lipid homeostasis in mice overexpressing DEPTOR in POMC neurons. Taken together, these results show that DEPTOR overexpression in POMC neurons does not affect energy balance regulation but could modu
The present study indicates that regulation of DEPTOR/mTOR signaling may be an important mechanism for glutamine in prevention against the development of colitis-associated colorectal cancer (CAC): the chemopreventive effect of dietary glutamine on CAC is, at least in part, associated with the induction of autophagy.
DEPTOR regulates liver inflammation at least partially via mTORC1 pathway, and is down-regulated by lypopolysaccharides through p65.
p38gamma and p38delta control heart growth by modulating mTOR pathway through DEPTOR phosphorylation and subsequent degradation.
DEPTOR plays a key role in maintaining stem cell pluripotency by limiting mTOR activity in undifferentiated embryonic stem cells
DEPTOR is induced by glucocorticoids during adipogenesis and that its overexpression promotes, while its suppression blocks, adipogenesis.
Data show that knockdown reduced Deptor mRNA and protein content by 90%, which increased phosphorylation of mTOR kinase substrates, 4E-BP1 and S6K1, and concomitantly increased protein synthesis.
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes (By similarity).
DEP domain containing MTOR-interacting protein
, DEP domain containing 6
, DEP domain containing mTOR interacting protein
, DEP domain-containing mTOR-interacting protein
, DEP domain-containing protein 6
, Rap guanine nucleotide exchange factor (GEF) 4