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anti-Human DEPTOR Antibodies:
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Human Polyclonal DEPTOR Primary Antibody for ICC, IF - ABIN4304935
Jegg, Ward, Iorns, Hoe, Zhou, Liu, Singh, Landgraf, Pegram: PI3K independent activation of mTORC1 as a target in lapatinib-resistant ERBB2+ breast cancer cells. in Breast cancer research and treatment 2012
Show all 8 Pubmed References
Human Polyclonal DEPTOR Primary Antibody for IF (p), IHC (p) - ABIN1387597
Liu, Zhang, Liu, Li, Zhang, Li, Liu, Huang, Shen, Gu, Gao, Wu, Wu: High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma. in OncoTargets and therapy 2015
key modulator that plays important roles in fine tuning the activity of mTOR and the activation state of the PI3K-AKT axis, with a deep impact on cancer, metabolism, and immunity [review]
Using computational modeling, systems analysis and dynamic simulations, study shows that DEPTOR confers remarkably rich and complex dynamic behaviours to mTOR signalling, including abrupt, bistable switches, oscillations and co-existing bistable/oscillatory responses. Transitions between these distinct modes of behavior are enabled by modulating DEPTOR expression alone.
In ASS1-knockout cells, DEPTOR, an inhibitor of mTORC1 signal, was downregulated and mTORC1 signaling was more activated in response to arginine.
Deptor depletion induces endoplasmic reticulum (ER) stress and synergizes the effect of the proteasome inhibitor bortezomib (Bz) in multiple myeloma (MM) cells.
DEPTOR overexpression is associated with cervical squamous cell carcinoma.
Studies provide evidence that Deptor appears to play an important role in the pathogenesis of many types of cancers, mainly through its role in controlling the activity of mTOR and many other possible functions. [review]
Low DEPTOR expression is associated with esophageal squamous cell carcinoma.
Association between insulin sensitivity and genetic variants in DEPTOR gene suggest DEPTOR and mammalian target of rapamycin signaling pathway to be potential target for future research and pharmacological interventions.
High DEPTOR expression is associated with T-cell leukemia.
Results provide evidence that DEPTOR acts as a tumor suppressor by limiting EGFR-driven lung adenocarcinoma progression.
that DEPTOR expression is required to maintain myeloma cell differentiation and high level of its expression are associated with better outcome.
High expression of DEPTOR benefits esophageal squamous cell carcinoma patients in early stage but not advanced stage.
the present findings supported the fact that DEPTOR-mTOR signaling is a central regulator of lipid metabolism-mediated inflammation in lymphocytes of PBMC culture.
In this study we began by validating the expression of four main mTOR pathway components, mTOR, DEPTOR, rictor and raptor, at gene and protein level in in vitro models of endometrioid (MDAH2774) and clear cell (SKOV3) ovarian cancer
Cul1 promoted mTORC1 activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR.
Propose regulation of placental SNAT2/LAT1 ubiquitination by mTORC1 and Nedd4-2.
Deptor enhances triple-negative breast cancer metastasis and chemoresistance through coupling to survivin expression
Data suggest that DEPTOR has a tumor suppressive activity against pancreatic cancer cells, and its loss of expression may contribute to pancreatic tumorigenesis.
Data indicate that phosphatidic acid (PA) specifically disrupts DEPTOR-mTORC1 interaction.
conclude that DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action in liver, and could be a novel target for anti-cancer therapy
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes (By similarity).
DEP domain containing MTOR-interacting protein
, DEP domain containing 6
, DEP domain containing mTOR interacting protein
, DEP domain-containing mTOR-interacting protein
, DEP domain-containing protein 6
, Rap guanine nucleotide exchange factor (GEF) 4