anti-Human FOXO1 antibody for Immunofluorescence (Cultured Cells)

Recommended FOXO1 Antibody (supplied by: Log in to see )

Antigen
Forkhead Box O1 (FOXO1) Antibodies
  • FOXO1
  • FOXO1A
  • fkh1
  • fkhr
  • foxo1a
  • xFoxO1
  • FKH1
  • FKHR
  • AI876417
  • Afxh
  • Fkhr1
  • Foxo1a
  • Fkhr
  • FoxO1A
  • FoxO1a.1
  • foxo1
  • zgc:153388
  • forkhead box O1
  • forkhead box O1 a
  • FOXO1
  • foxo1
  • Foxo1
  • foxo1a
Reactivity
Human, Mouse (Murine)
471
254
202
35
29
21
14
12
8
7
5
3
3
3
3
2
2
1
1
Host
Rabbit
321
134
21
2
Clonality
Monoclonal
Conjugate
This FOXO1 antibody is un-conjugated
11
11
9
8
8
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
2
2
1
1
Application
Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
381
208
136
134
131
83
56
12
9
9
5
4
4
4
3
3
2
Options
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Catalog No. ABIN5557370
$ 401.50
Plus shipping costs $45.00

General

Antigen Forkhead Box O1 (FOXO1) Antibodies
Reactivity Human, Mouse (Murine)
(471), (254), (202), (35), (29), (21), (14), (12), (8), (7), (5), (3), (3), (3), (3), (2), (2), (1), (1)
Host Rabbit
(321), (134), (21), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This FOXO1 antibody is un-conjugated
(11), (11), (9), (8), (8), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (2), (2), (1), (1)
Application Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(381), (208), (136), (134), (131), (83), (56), (12), (9), (9), (5), (4), (4), (4), (3), (3), (2)
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Product Details anti-FOXO1 Antibody

Target Details FOXO1 Application Details Handling Images
Purification Purified by Protein A.
Immunogen Recombinant human FOXO1A protein, around 300-400aa.
Clone 3G1
Isotype IgG

Target Details FOXO1

Product Details anti-FOXO1 Antibody Application Details Handling Images back to top
Antigen
Alternative Name FOXO1A (FOXO1 Antibody Abstract)
Background

Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.

Synonyms: Forkhead box protein O1, FOXO1, Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma, FOXO1, FKHR, FOXO1A

Gene ID 2308
UniProt Q12778
Research Area Cancer, Transcription Factors
Pathways PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events

Application Details

Product Details anti-FOXO1 Antibody Target Details FOXO1 Handling Images back to top
Application Notes WB 1:1000-2000
IHC-P 1:50-200
IF(ICC) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-FOXO1 Antibody Target Details FOXO1 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-FOXO1 Antibody Target Details FOXO1 Application Details Handling back to top
Supplier Images
Western Blotting (WB) image for anti-Forkhead Box O1 (FOXO1) antibody (ABIN5557370) Lane 1: HeLa lysates, Lane 2: NIH/3T3 lysates, probed with FOXO1A (3G1) Monoclonal An...
Immunofluorescence (Cultured Cells) (IF (cc)) image for anti-Forkhead Box O1 (FOXO1) antibody (ABIN5557370) 3T3 cells were fixed in paraformaldehyde, permeabilized with 0.25% Triton X100/PBS an...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Forkhead Box O1 (FOXO1) antibody (ABIN5557370) Paraformaldehyde-fixed, paraffin embedded mouse brain tissue, Antigen retrieval by bo...