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Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA\; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.
glutamate receptor, ionotrophic, AMPA 4
, AMPA receptor GluR4/D
, glutamate receptor subunit GluR4
, glutamate receptor 4
, AMPA-selective glutamate receptor 4
, glutamate receptor, ionotropic, AMPA4 (alpha 4)
, glutamate receptor channel alpha 4
, glutamate receptor ionotropic, AMPA 4
, spike wave 1