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BCL2 (show BCL2 Proteins) expression in mesennchymal lung cancer cells was induced by ERK1 (show MAPK3 Proteins) activity through the upregulation of the MEK1 (show MAP2K1 Proteins)/ERK1 (show MAPK3 Proteins) scaffold protein (show HOMER1 Proteins) MEK partner-1. Interfering with the MEK1 (show MAP2K1 Proteins)/MP1 (show PITRM1 Proteins)/ERK1 (show MAPK3 Proteins) axis using a MEK1 (show MAP2K1 Proteins) inhibitor or MP1 (show PITRM1 Proteins) depletion repressed BCL2 (show BCL2 Proteins) expression and sensitized MLCCs to chemoradiotherapy.
The present study was aimed at investigating whether the miR (show MLXIP Proteins)-29c binding site single nucleotide polymorphisms within the 3'-UTRs of LAMTOR3 gene affected the gastric cancer risk.
we demonstrate that the MAPK (show MAPK1 Proteins) scaffold protein (show HOMER1 Proteins) MEK partner 1 (MP1) is important for gastrin (show GAST Proteins)-induced phosphorylation of ERK1 (show MAPK3 Proteins) and ERK2 (show MAPK1 Proteins) and that MP1 (show PITRM1 Proteins) promotes gastrin (show GAST Proteins)-induced proliferation of AGS (show JAG1 Proteins)-GR cells
identified polymorphisms in LAMTOR2 (show LAMTOR2 Proteins) and LAMTOR3 do not seem to play a relevant role in breast cancer
A complex encoded by the MAPKSP1, ROBLD3 (show LAMTOR2 Proteins), and c11orf59 (show LAMTOR1 Proteins) genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation
We investigated the neuroprotective effect of glial-derived neurotrophic factor (GDNF) upon alcohol-exposed B92 cultures, as well as the role of the cytoskeleton and mitogen-activated protein kinase (show MAPK1 Proteins) (MAPK (show MAPK1 Proteins)) pathways in this effect.
This novel mechanism for localization of intracellular Leishmania amazonensis-mediated ERK1/2 phosphorylation required the endosomal scaffold protein MP1 and localized to Leishmania amazonensis parasitophorous vacuoles.
We show an essential function for late endosomes carrying the p14 (show PCOLCE Proteins)-MP1 (LAMTOR2 (show LAMTOR2 Proteins)/3) complex in focal adhesion dynamics.
Data indicate that LAMTOR3 protein is stabilized by associating with LAMTOR2 (show LAMTOR2 Proteins).
A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation.
MP1 and the MP1*P14 complex have the potential to differentially modulate activating and inhibiting signals in the Raf-MKK1/2-ERK1/2 pathway.
This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13.
MAPK scaffold protein 1
, mitogen-activated protein kinase kinase 1 interacting protein 1
, MEK binding partner 1
, late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
, mitogen-activated protein kinase scaffold protein 1
, ragulator complex protein LAMTOR3
, MEK-binding partner 1
, mitogen activated protein, binding protein
, mitogen-activated protein kinase kinase 1-interacting protein 1
, MEK partner 1
, Mitogen-activated protein kinase kinase 1-interacting protein 1
, Mitogen-activated protein kinase scaffold protein 1
, putative mitogen-activated protein kinase kinase 1 interacting protein 1