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Human MTOR Protein expressed in HEK-293 Cells - ABIN2726555
Yin, Hua, Li, Liu, Kong, Shao, Wang, Luo, Wang, Luo, Jiang: mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR. in Cell research 2016
Studied combination of metformin and nutlin-3a on malignant mesothelioma. Results indicate possible interactions between metformin/nutlin-3a and mTOR and p53 (show TP53 Proteins) signal pathways.
AKAP1 (show AKAP1 Proteins) is a transcriptional target of Myc (show MYC Proteins), and it supports mTOR pathway and the growth of cancer cells.
Studies indicate that understanding mTOR network circuitry will provide insight into its deregulation in diabetes, cancer, and cardiovascular disease, but modeling in silico to elucidate how insulin (show INS Proteins) activates mTORC2 (show CRTC2 Proteins) remains poorly defined.
Our data indicated that miR (show MLXIP Proteins)-451 relays environmental signals by upregulating the activity of AMPK (show PRKAA1 Proteins) signaling, thereby modulating the activation of mTOR and Rac1/cofilin (show CFL1 Proteins) which, in turn, play key roles in glioma cell proliferation and migration, respectively. Our results highlight the need to consider opposing roles of a therapeutic target which, while suppressing tumor cell proliferation, could also promote cell infiltratio
Combining a dual PI3K (show PIK3CA Proteins)/mTOR inhibitor with MEK (show MAP2K1 Proteins) inhibitors may be a relevant approach to increase anti-tumor activity and prevent drug resistance in patients with leiomyosarcomas.
Suggest that hyperactivation of the mTOR pathway is involved in the development of endometrial hyperplasia with aging.
our findings suggested that MCM7 (show MCM7 Proteins) promoted tumor cell proliferation, colony formation and migration of ESCC cells via activating AKT1 (show AKT1 Proteins)/mTOR signaling pathway
MED15 (show MED15 Proteins) overexpression arises during androgen deprivation therapy via hyper-activation of PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/mTOR signaling pathway in prostate cancer cells.
Telmisartan suppressed human esophageal adenocarcinoma cell proliferation and tumor growth by inducing cell cycle arrest via the AMPK (show PRKAA1 Proteins)/mTOR pathway.
mTOR signaling contributes to PGRN (show GRN Proteins)-stimulated carcinogenesis of cervical cancer
mTOR mediates metabolic adaptation of antigen-presenting cells in distinct tissues, influencing the immunological character of allergic inflammation.
mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR (show VLDLR Proteins) Loss
our results show that the phosphorylation of 4E-BP1 (show EIF4EBP1 Proteins) promotes translation at the onset of meiosis to support the spindle assembly and suggest an important role of CDK1 (show CDK1 Proteins) and mTOR kinases in this process
Inhibition of mTOR complex 1 is closely associated with aging and prolonged life span of fission yeast.
Abeta (show APP Proteins) increases the expression of mTOR and p-mTOR at the site of Ser2448, and the stimulation of Abeta (show APP Proteins) is likely to depend on sirtuin 1 (show SIRT1 Proteins), PPARgamma (show PPARG Proteins), and PGC-1beta pathway in regulating mTOR expression.
In mTOR gene deletion, the astrocyte population exhibited a lower seizure frequency compared with controls in an animal model of temporal lobe epilepsy.
UVB-irradiated or aged mice skin revealed that mTORC2 (show CRTC2 Proteins) activity was significantly upregulated which in turn increased Akt (show AKT1 Proteins) activation and Akt (show AKT1 Proteins)-dependent IkappaB kinase alpha (show CHUK Proteins) (IKKalpha (show CHUK Proteins)) phosphorylation, and The increased mTORC2 (show CRTC2 Proteins) signaling pathway during skin aging were associated to NF-kappaB (show NFKB1 Proteins) activation.
Mitogen-activated protein kinase (show MAPK1 Proteins) interacting protein (show CIB1 Proteins) kinases (Mnks) control translation by phosphorylation of eIF4E (show EIF4E Proteins), whereas the mTOR kinase phosphorylates/de-activates the eIF4E (show EIF4E Proteins) inhibitor, 4E-BP1 (show EIF4EBP1 Proteins), to release translational repression.
This study reveals the dramatic rescue effects of L-leucine stimulation of mTORC1 in RBS (show ESCO2 Proteins) cells and supports that normal gene expression and translation requires ESCO2 (show ESCO2 Proteins) function.
By inhibiting mTOR signaling via Fbxw7 (show FBXW7 Proteins), the amount of myelination during development is reduced.
Apc mutations activate mechanistic target of rapamycin complex 1 in mice and zebrafish
In our zebrafish model, autophagy induction does not depend on inhibition of the Tor pathway or activation of Tp53 (show TP53 Proteins).
TOR signaling is a common pathological pathway that can be leveraged for therapeutic benefits in cardiomyopathies of different origins.
in addition to regulating cell growth and proliferation, TOR signaling controls the developmental program guiding epithelial morphogenesis in the intestine
The immunoprecipitation results also showed that high AA concentrations significantly increased the interaction of mTOR and PPARg (show PPARG Proteins). In summary, PPARg (show PPARG Proteins) plays an important role in the regulation of IGF-1 (show IGF1 Proteins) secretion and gene expression in response to dietary protein.
These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt-mTOR-FOXO1 signaling and suppressing the activation of TLR4 and/or NOD2 signaling pathways.
Data show that the amount of proteins related to mechanistic target of rapamycin (mTOR) signaling pathways decreased along crypt-villus axis (CVA).
AMPK (show PRKAA1 Proteins)-mTOR-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Uroguanylin (show GUCA2B Proteins) modulates (Na++K+)ATPase (show ATP1A1 Proteins) in a proximal tubule cells via cGMP/protein kinase (show CDK7 Proteins) G, cAMP/protein kinase A, and mTOR pathways.
mTOR is involved in 17beta-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1 (show CCND1 Proteins), and CCNE1 (show CCNE1 Proteins).
L-Glutamine enhances enterocyte growth via activation of the mTOR.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR-RPS6K-RPS6 (show RPS6 Proteins)-EIF4EBP1 (show EIF4EBP1 Proteins) signal transduction pathway.
Data indicate that the expression of MAP1LC3A (show MAP1LC3A Proteins), B and autophagy-associated genes (ATG5 (show ATG5 Proteins), mTOR, Beclin-1 (show BECN1 Proteins)) was increased in normal pigs, while decreased in miniature pigs.
Biochemical, cellular, and molecular data suggest that L-arginine (show GATM Proteins) stimulates mTOR biosynthesis, mTOR signaling, and overall protein biosynthesis/turnover in placental/trophoblast and blastocyst/ectoderm cells thereby enhancing cell proliferation.
AnxA2 (show ANXA2 Proteins) functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c (show SREBF1 Proteins)/Cyclin D1 (show CCND1 Proteins) signaling pathway.
These findings suggest that mTOR is involved in the control of the expression of multiple genes in cattle, which may be triggered by the luteinizing hormone surge.
14-3-3gamma (show YWHAG Proteins) affects mTOR protein pathway and regulates lactogenesis in dairy cow mammary epithelial cells.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2 (show JAK2 Proteins)-STAT5 (show STAT5A Proteins) and mTOR signaling pathways.
Insulin (show INS Proteins)-induced activation of phosphoinositide 3-kinase~mTOR pathway up-regulates tau protein via acceleration of protein synthesis in adrenal chromaffin cells, promoting neurite-like process outgrowth.
IGF-I (show IGF1 Proteins) down-regulated functional IGF-I receptor (show IGF1R Proteins) via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor (show IGF1R Proteins) level in nonstimulated cells.
stimulation of mammary protein synthesis by amino acids and its enhancement by a combination of the lactogenic hormones hydrocortisone, insulin (show INS Proteins), and prolactin (show PRL Proteins) were associated with increased phosphorylation of the mTOR substrates
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2.
prostaglandin F2alpha phosphorylates TSC2 and activates mTOR and ribosomal protein S6 (show RPS6 Proteins) kinase (show RPS6KB1 Proteins) signaling in an AKT (show AKT1 Proteins)-independent manner
mTOR links IGF-I (show IGF1 Proteins) and EGF (show EGF Proteins) signaling in inhibiting the autophagy pathways.
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene.
FK506 binding protein 12-rapamycin associated protein 1
, FK506 binding protein 12-rapamycin associated protein 2
, FK506-binding protein 12-rapamycin complex-associated protein 1
, FKBP-rapamycin associated protein
, FKBP12-rapamycin complex-associated protein 1
, mammalian target of rapamycin
, rapamycin and FKBP12 target 1
, rapamycin associated protein FRAP2
, rapamycin target protein 1
, serine/threonine-protein kinase mTOR
, FKBP-rapamycin associated protein (FRAP)
, FKBP-rapamycin-associated protein FRAP
, FKBP12-rapamycin complex-associated protein
, angiopoietin-like factor CDT6
, rapamycin and FKBP12 target-1 protein
, target of rapamycin