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anti-Human PHLPP1 Antibodies:
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Human Polyclonal PHLPP1 Primary Antibody for IP - ABIN151319
Brognard, Niederst, Reyes, Warfel, Newton: Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. in The Journal of biological chemistry 2009
Show all 7 Pubmed References
Human Polyclonal PHLPP1 Primary Antibody for IP, WB - ABIN151320
Hirano, Nakamura, Yokota, Ono, Shigeno, Fujisawa, Shinjo, Ohnishi et al.: Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt ... in The Journal of biological chemistry 2009
Show all 5 Pubmed References
Data suggest a tumor suppressor role of Xist in inhibiting AKT (show AKT1 Antibodies) activation via regulation of non-X-chromosome gene PHLPP1 expression.
Low PHLPP expression is associated with gallbladder cancer.
nickel exposure results in DNMT3b (show DNMT3B Antibodies) induction and MEG3 (show FAM129B Antibodies) promoter hypermethylation and expression inhibition, further reduces its binding to c-Jun (show JUN Antibodies) and in turn increasing c-Jun (show JUN Antibodies) inhibition of PHLPP1 transcription, leading to the Akt (show AKT1 Antibodies)/p70S6K (show RPS6KB1 Antibodies)/S6 axis activation, and HIF-1alpha (show HIF1A Antibodies) protein translation, as well as malignant transformation of human bronchial epithelial cells.
Data suggest that PHLPP1 plays an important role in assembly of kinetochores by counteracting RNF41 (show RNF41 Antibodies)-mediated SGT1 (show SUGT1 Antibodies) degradation. (PHLPP1 = PH domain and leucine rich repeat protein phosphatase 1; RNF41 (show RNF41 Antibodies) = ring finger protein 41 (show RNF41 Antibodies); SGT1 (show SUGT1 Antibodies) = suppressor of G2 allele of SKP1 (show SUGT1 Antibodies))
Studies indicate that two PHLPP isozymes, PHLPP1 and PHLPP2 (show PHLPP2 Antibodies), were identified in a search for phosphatases that dephosphorylate Akt (show AKT1 Antibodies), and thus suppress growth factor signaling.
During LPS (show IRF6 Antibodies) induced macrophage inflammatory response, PHLPP levels in macrophages are depleted through the inhibition of SP1 (show PSG1 Antibodies) dependent transcriptional regulation.
results identify a novel role of PHLPP in regulating aPKC and cell polarity.
Abnormal PHLPP, FoxO3a (show FOXO3 Antibodies), and RAD51 (show RAD51 Antibodies) protein expressions may be involved in the development of high- and low-grade ovarian serous adenocarcinomas, suggesting common molecular pathways.
this study shows that PHLPP1 played a suppression role in inflammatory response of glioma
Increased PHLPP expression is associated with pancreatic cancer.
Results strengthen the roles of both calpain-1 (show CAPN1 Antibodies) and PHLPP1 in synaptic plasticity and learning and memory, and illustrate the complexities of the interactions between multiple pathways participating in synaptic plasticity.
PHLPP1 reduced IFN-gamma (show IFNG Antibodies)-stimulated but not LPS (show TLR4 Antibodies)-induced ERK1/2 (show MAPK1/3 Antibodies) phosphorylation, and inhibition of ERK1/2 (show MAPK1/3 Antibodies) abolished IFN-gamma-induced (show SAMHD1 Antibodies) ser (show SIGLEC1 Antibodies)(727) STAT1 (show STAT1 Antibodies) phosphorylation and iNOS (show NOS2 Antibodies) expression.
Phlpp1 deficiency increases Akt2 (show AKT2 Antibodies) activity, which diminishes FoxO1 (show FOXO1 Antibodies) levels and induces Fgf18 (show FGF18 Antibodies) expression to stimulate chondrocyte proliferation.
enhancing Akt (show AKT1 Antibodies) activity by inhibiting its PHLPP1-mediated dephosphorylation promotes processes associated with physiological hypertrophy
data are consistent with a model in which PHLPP modifies the histone code to control the transcription of RTKs.
SRPK1 (show SRPK1 Antibodies) overexpression is also tumorigenic because excess SRPK1 (show SRPK1 Antibodies) squelches PHLPP1.
PHLPP is a negative regulator of RAF1 (show RAF1 Antibodies), which reduces colorectal cancer cell motility and prevents tumor progression in mice.
Histone deacetylase 3 (show HDAC3 Antibodies) suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt (show AKT1 Antibodies) signaling and matrix secretion
deletion of PHLPP1 can enhance Akt (show AKT1 Antibodies) activation in neurons and astrocytes, and can significantly increase cell survival and diminish infarct size
This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.
PH domain and leucine rich repeat protein phosphatase 1
, PH domain leucine-rich repeat-containing protein phosphatase 1-like
, PH domain leucine-rich repeat-containing protein phosphatase 1
, PH domain-containing family E member 1
, SCN circadian oscillatory protein
, pleckstrin homology domain containing, family E (with leucine rich repeats) member 1
, suprachiasmatic nucleus circadian oscillatory protein
, pleckstrin homology domain-containing family E member 1
, Circadian Oscillatory Protein (SCOP)
, PH domain leucine-rich repeat protein phosphatase 1
, pleckstrin homology domain-containing family E protein 1