Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
BPGAP1 (show ARHGAP8 Proteins) provides a crucial spatiotemporal checkpoint where JNK (show MAPK8 Proteins) and MP1 (show PITRM1 Proteins)/MEK1 (show MAP2K1 Proteins) work in concert to regulate endosomal and nuclear ERK (show EPHB2 Proteins) signaling in cell proliferation control.
Pin1 (show PIN1 Proteins) regulates BPGAP1 (show ARHGAP8 Proteins) function in Rho and Erk (show EPHB2 Proteins) signalling, with active Mek2 (show MAP2K2 Proteins) serving as a novel regulatory scaffold that promotes crosstalk between RhoGAP (show ARHGAP1 Proteins), Pin1 (show PIN1 Proteins) and Erk (show EPHB2 Proteins) in the regulation of cell migration.
mRNA expression analyses revealed PRR5 overexpression in a majority of colorectal tumors but substantial downregulation of PRR5 expression in a subset of breast tumors and reduced expression in two breast cancer cell lines
It was demonstrated that immunoprecipitation of Protor-1 or Protor-2 (show PRR5L Proteins) results in the co-immunoprecipitation of other mTORC2 (show CRTC2 Proteins) subunits, but not Raptor (show RPTOR Proteins), a specific component of mTORC1.
The inhibition of Akt (show AKT1 Proteins) and S6K1 (show RPS6KB1 Proteins) phosphorylation by PRR5 knock down correlates with reduction in the expression level of platelet-derived growth factor receptor beta (show PDGFRB Proteins) (PDGFRbeta).
BPGAP1 (show ARHGAP8 Proteins) has a role in regulating cell dynamics with BNIP-2 (show BNIP2 Proteins) and Cdc42GAP (show ARHGAP1 Proteins) homology/Sec14p-like, proline-rich, and GTPase-activating protein (show RASA1 Proteins) domains of BPGAP1 (show ARHGAP8 Proteins)
RhoGAP (show ARHGAP1 Proteins) functionally interacts with cortactin (show CTTN Proteins) and represents a novel determinant in the regulation of cell dynamics.
ARHGAP8 (show ARHGAP8 Proteins) expression was up-regulated in the majority of primary colorectal tumors analyzed in this work.
BPGAP1 (show ARHGAP8 Proteins) is a novel RhoGAP (show ARHGAP1 Proteins) that co-ordinately regulates pseudopodia and cell migration through the interplay of its BNIP-2 (show BNIP2 Proteins) and Cdc42GAP (show ARHGAP1 Proteins) homology domains.
findings reveal a concomitant activation of endocytosis and ERK (show EPHB2 Proteins) signaling by BPGAP1 (show ARHGAP8 Proteins) via the coupling of its proline-rich region, which targets EEN (show SH3GL1 Proteins) and its functional GAP domain
This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
BCH domain-containing Cdc42GAP-like protein
, BNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1
, rho GTPase-activating protein 8
, rho-type GTPase-activating protein 8
, proline-rich protein 5
, protein observed with Rictor-1
, Rho GTPase activating protein 8
, Protor-2 homolog
, proline rich 5 (renal)
, proline rich protein 5