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Human CYR61 ELISA Kit for Sandwich ELISA - ABIN421897
Catoire, Mensink, Kalkhoven, Schrauwen, Kersten: Identification of human exercise-induced myokines using secretome analysis. in Physiological genomics 2014
This study is the first to describe how CCN1 promotes VEGF expression in osteoblasts and increased endothelial progenitor cells angiogenesis in rheumatoid arthritis disease.
Data show that cysteine rich protein 61 protein (CCN1) critically mediates doxorubicin (DOX)-induced cardiotoxicity.
Our results not only reveal a novel mechanism illustrating the role of Cyr61 in epidermis pathogenesis but also suggest that therapies targeting Cyr61 may represent a novel strategy in the treatment of psoriasis vulgaris.
The LPA1 (show LPAR1 ELISA Kits)-CCN1 (show CCNA2 ELISA Kits) axis may be the central control for SMC (show DYM ELISA Kits) migration.
these data suggest that the WNT (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway enhances pancreatic cancer development and malignancy in part via up-regulation of CYR61.
Lysophosphatidic acid induced time-dependent phosphorylation of serum response factor and CRE-binding protein in in smooth muscle cells, inducing transcription of CCN1.
Data show that Cysteine-rich 61 (CYR61) acts as a tumor-promoting gene in pancreatic neuroendocrine tumors.
CCN1 is an important regulator of chondrocyte maturation during cartilage development and homeostasis.
CCN1 exacerbates tracheal obliterative bronchiolitis by enhancing fibroproliferation via an alphavbeta3-integrin-independent pathway.
Data show that RNA silencing of CCN family member 1 protein (CCN1 (show CCNA2 ELISA Kits)) inhibits retinal neovascularization (RNV) by inhibiting phosphoinositide 3-kinase (PI3K)/AKT (show AKT1 ELISA Kits) protein signaling in mouse pup model of oxygen-induced retinopathy (OIR).
Knockdown of CYR61 in gastric cancer AGS (show JAG1 ELISA Kits) cells impairs the cancer cell migration and invasion, suggesting a driver role of CYR61 in metastasis.
Two interacting partners of urokinase-type plasminogen activator (uPA) receptor (show PLAUR ELISA Kits), the cysteine-rich angiogenic inducer 61 (Cyr61) and the Y-box-binding protein 1 (YB-1 (show YBX1 ELISA Kits)) were identified and their differential expression demonstrated in the triple-negative breast cancer (TNBC) cells as well as in tumors.
collagen II-activated phosphorylated-DDR2 (show DDR2 ELISA Kits) induces CYR61 through activation of transcription factor activator protein 1 (AP-1 (show FOSB ELISA Kits)). The elevated CYR61, in turn, accelerates MMP1 (show MMP1 ELISA Kits) production via ETS1 (ETS (show ETS1 ELISA Kits) proto-oncogene (show RAB1A ELISA Kits) 1).
Cyr61 stimulated MMP-3 (show MMP3 ELISA Kits) production in fibroblast-like synoviocytes of rheumatoid arthritis patients.
Low CCN1 expression is associated with esophageal cancer.
this study found that expression of Cyr61 was higher in the ectopic endometrium than in the eutopic endometrium and that Cyr61 expression in the endometrium was correlated with age, number of natural labors, blood loss, uterine volume, adenomyosis type, and concurrent endometriosis
The role of CYR61 in aromatase (show CYP19A1 ELISA Kits) inhibitors resistance in estrogen receptor (show ESR1 ELISA Kits) positive breast cancer patients
CYR61 is a TGF-beta (show TGFB1 ELISA Kits)-induced stromal-derived factor that regulates gemcitabine sensitivity in pancreatic ductal adenocarcinoma.
These studies support previously unrecognized, cooperative interaction between the CCN1 (show CCNA2 ELISA Kits) matricellular protein and canonical TGF-beta1 (show TGFB1 ELISA Kits)/SMAD3 (show SMAD3 ELISA Kits) signaling that promotes lung fibrosis.
The increased expression of CYR61 in the Day 4 corpus lutum (CL) and its transient increase by prostaglandin F2alpha in Day 6, Day 10, and Day 16 CL indicate that CYR61 may play a role in regulating angiogenesis over the life span of the CL.
Together, these results indicate that Cyr61 is an important determinant of the genetic reprogramming that occurs in mechanically challenged cells.
Mechanical regulation of the Cyr61 gene in smooth muscle cells
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation.
cysteine-rich, angiogenic inducer, 61
, SMT3 suppressor of mif two 3 homolog 3
, small ubiquitin-related modifier 3
, protein CYR61-like
, CCN family member 1
, IGF-binding protein 10
, cysteine-rich angiogenic inducer 61
, insulin-like growth factor binding protein 10
, insulin-like growth factor-binding protein 10
, intermediate early
, protein CYR61
, cysteine-rich heparin-binding protein 61
, cysteine-rich, anigogenic inducer, 61
, cysteine rich protein 61
, secreted cysteine-rich protein cyr61