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This study provides the first genetic mutant analyses of zebrafish foxq1a and foxq1b. Foxq1a, but not foxq1b, was transcriptionally regulated during a bacterial response, while the expression of foxq1a was detected in sorted macrophages and upregulated in foxq1a-deficient mutants.
Results show that FOXQ1, a well-known oncogenic protein and promoter of gastric cancer (GC) metastasis, to be the direct downstream target of miR (show MLXIP Proteins)-345 in GC. Its mRNA and protein levels are up-regulated in GC tumors.
These data identify FOXQ1 as a melanoma suppressor.
Results revealed that, co-culture with TAMs promoted the invasion and migration of GC cells. Co-culture with TAMs induced EMT (show ITK Proteins) in GC cells. FOXQ1 is essential for TAM (show CCNA1 Proteins)-induced EMT (show ITK Proteins) and metastasis in GC cells.
FOXQ1 remarkably inhibited the replicative senescence through depressing the expression of the inflammatory cytokines interleukin-6 (IL-6 (show IL6 Proteins)) and IL-8 (show IL8 Proteins) via modulation of SIRT1 (show SIRT1 Proteins)-NF-kappaB (show NFKB1 Proteins) pathway.
Cell viability and progression from G1 to S phase were both improved with overexpression of Foxq1, and microRNAs profiling study and dual-luciferase result suggested miR (show MLXIP Proteins)-320b contributed to the up-regulation of Foxq1 after calcium hydroxide stimulation. These results suggested that miR (show MLXIP Proteins)-320b mediated Foxq1 up-regulation promote proliferation of dental pulp stem cells.
We identified FOXM1 (show FOXM1 Proteins) and FOXQ1 as novel prognostic biomarkers in colorectal cancer and miR (show MLXIP Proteins)-342 as a novel regulator of both FOXM1 (show FOXM1 Proteins) and FOXQ1
Data indicate a role for the miR (show MLXIP Proteins)-320/SOX4/FOXM1 (show FOXM1 Proteins)/FOXQ1 axes in promoting colorectal cancer (CRC (show CALR Proteins)) development and suggest targeting those networks as potential therapeutic strategy for CRC (show CALR Proteins).
MiR (show MLXIP Proteins)-133 directly targeted and down-regulated FOXQ1 expression, which in turn reduced TGF-beta (show TGFB1 Proteins) level.
There are several modes of regulation of FOXQ1 expression that have been demonstrated in normal and tumor cells, such as microRNA and the Wnt (show WNT2 Proteins) signaling pathway. The activation of FOXQ1 affects downstream genes promoting the initiation, proliferation and invasion, in addition to the metastasis of tumor cells
FOXQ1 is a prognostic marker for patients with Gastric cancer, FOXQ1 over-expression is involved in acquisition of the mesenchymal phenotype of gastric cancer cells, and subsequent Snail (show SNAI1 Proteins) expression is essential for induction of Epithelial-Mesenchymal Transition.
FOXQ1 is a novel factor involved in regulating hepatic gluconeogenesis, and the decreased FOXQ1 expression in liver may contribute to the development of type 2 diabetes.
R164C mutation in FOXQ1 H3 domain affects formation of the hair medulla in mice.
This study has elucidated the functional impact of FoxQ1 on epithelial differentiation.
satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation
Ultrastructural analysis suggests that the gastric acid secretion defect in Foxq1-deficient mice might be due to impairment in the fusion of cytoplasmic tubulovesicles to the apical membrane of secretory canaliculi.
Transcription factor foxq1 controls MUC5AC gene expression and granule content in mouse stomach surface mucous cells.
FOXQ1 is a member of the FOX gene family, which is characterized by a conserved 110-amino acid DNA-binding motif called the forkhead or winged helix domain. FOX genes are involved in embryonic development, cell cycle regulation, tissue-specific gene expression, cell signaling, and tumorigenesis (Bieller et al., 2001
forkhead box Q1
, forkhead transcription factor Q1
, fork-head box Q1 transcription factor
, HNF-3/forkhead-like protein 1
, forkhead box protein Q1
, hepatocyte nuclear factor 3 forkhead homolog 1
, winged helix/forkhead transcription factor
, HNF-3/forkhead homolog 1 like
, HNF-3/forkhead homolog-1