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We identified FOXM1 (show FOXM1 Proteins) and FOXQ1 as novel prognostic biomarkers in colorectal cancer and miR (show MLXIP Proteins)-342 as a novel regulator of both FOXM1 (show FOXM1 Proteins) and FOXQ1
Data indicate a role for the miR (show MLXIP Proteins)-320/SOX4/FOXM1 (show FOXM1 Proteins)/FOXQ1 axes in promoting colorectal cancer (CRC (show CALR Proteins)) development and suggest targeting those networks as potential therapeutic strategy for CRC (show CALR Proteins).
MiR (show MLXIP Proteins)-133 directly targeted and down-regulated FOXQ1 expression, which in turn reduced TGF-beta (show TGFB1 Proteins) level.
There are several modes of regulation of FOXQ1 expression that have been demonstrated in normal and tumor cells, such as microRNA and the Wnt (show WNT2 Proteins) signaling pathway. The activation of FOXQ1 affects downstream genes promoting the initiation, proliferation and invasion, in addition to the metastasis of tumor cells
FOXQ1 is a prognostic marker for patients with Gastric cancer, FOXQ1 over-expression is involved in acquisition of the mesenchymal phenotype of gastric cancer cells, and subsequent Snail (show SNAI1 Proteins) expression is essential for induction of Epithelial-Mesenchymal Transition.
our study suggests that FOXQ1 regulates prostate cancer cell proliferation and apoptosis by regulating BCL11A (show BCL11A Proteins)/MDM2 (show MDM2 Proteins) expression and indicates that FOXQ1 may serve as a potential therapeutic target for prostate cancer.
The miR (show MLXIP Proteins)-506/FOXQ1 axis plays an important role in the pathogenesis of cervical cancer.
DATS administration inhibited ALDH1 (show ALDH1A1 Proteins) activity in vivo in SUM159 xenografts. These results indicate that FoxQ1 is a novel target of bCSC inhibition by DATS.
Data suggest that forkhead box Q1 (FOXQ1) is a potential therapeutic target for the development of therapies for colorectal cancer.
we identified FOXQ1 as an oncogene (show RAB1A Proteins) to promote ESCC tumor cell proliferation and metastasis by negatively regulating CDH1 (show CDH1 Proteins) in esophageal squamous cell carcinoma cells
FOXQ1 is a novel factor involved in regulating hepatic gluconeogenesis, and the decreased FOXQ1 expression in liver may contribute to the development of type 2 diabetes.
R164C mutation in FOXQ1 H3 domain affects formation of the hair medulla in mice.
This study has elucidated the functional impact of FoxQ1 on epithelial differentiation.
satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation
Ultrastructural analysis suggests that the gastric acid secretion defect in Foxq1-deficient mice might be due to impairment in the fusion of cytoplasmic tubulovesicles to the apical membrane of secretory canaliculi.
Transcription factor foxq1 controls MUC5AC gene expression and granule content in mouse stomach surface mucous cells.
FOXQ1 is a member of the FOX gene family, which is characterized by a conserved 110-amino acid DNA-binding motif called the forkhead or winged helix domain. FOX genes are involved in embryonic development, cell cycle regulation, tissue-specific gene expression, cell signaling, and tumorigenesis (Bieller et al., 2001
forkhead box Q1
, forkhead transcription factor Q1
, fork-head box Q1 transcription factor
, HNF-3/forkhead-like protein 1
, forkhead box protein Q1
, hepatocyte nuclear factor 3 forkhead homolog 1
, winged helix/forkhead transcription factor
, HNF-3/forkhead homolog 1 like
, HNF-3/forkhead homolog-1