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RACK1 (show GNB2L1 Proteins) associates with MOAP-1 via electrostatic associations similar to those observed between MOAP-1/RASSF1A (show RASSF1 Proteins) and MOAP-1/TNF-R1 (show TNFRSF1A Proteins). These events illustrate the complex nature of MOAP-1 regulation and characterizes the important role of the scaffolding protein, RACK1 (show GNB2L1 Proteins), in influencing MOAP-1 biology.
These findings reveal a role for MOAP-1 in Fas (show FAS Proteins) signaling in the liver by promoting MTCH2 (show MTCH2 Proteins)-mediated tBid recruitment to mitochondria.
UBR5 downregulates proapoptotic MOAP-1 and suggest that UBR5 can confer cisplatin resistance in ovarian cancer.
Paraneoplastic Ma antigen-like 1 is suggested as a novel potential clinically useful prognostic biomarker for patients with pancreatic ductal adenocarcinoma.
PNMA2 functions as antagonist of MOAP-1 and PNMA1 (show PNMA1 Proteins) through heterodimeric interaction
MOAP-1 is a tumor suppressor protein (show TP53 Proteins) linked to the RASSF1A (show RASSF1 Proteins) protein
miR (show MLXIP Proteins)-25 promotes cell proliferation and inhibits apoptosis in non-small cell lung cancer cells by negatively regulating MOAP1 expression.
PB1 (show SMR3A Proteins)-F2 protein of influenza A virus interacts with human MOAP-1 protein.
Enforced miR (show MLXIP Proteins)-1228 expression can reduce MOAP1 expression and delay the progression of stress-induced cell apoptosis.
RASSF1A (show RASSF1 Proteins) and MAP-1 (show MASP1 Proteins) are important components between death receptors and the apoptotic machenery.
MAP-1 is a direct mitochondrial target of Bax (show BAX Proteins).
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.
modulator of apoptosis 1
, paraneoplastic Ma antigen family member 4
, paraneoplastic antigen Ma4
, paraneoplastic antigen like 4