Browse our SEMA7A Proteins (SEMA7A)

Mouse (Murine) Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group) (SEMA7A) interaction partners

1. During differentiation of adult-born dentate gyrus granule cells, Sema7A promotes dendrite growth, complexity and spine development through beta1-subunit-containing integrin receptors.

2. Genetic ablation of host-derived SEMA7A further enhanced the antitumor effects of SEMA7A shRNA gene silencing in 4T1 cells. Our preclinical findings demonstrate a critical role for SEMA7A in mediating mammary tumor progression.

3. sema7A is involved in peripheral immunity and central nervous system inflammation in multiple sclerosis pathogenesis.

4. These findings indicate that Sema7A as a potent activator of T cells and monocytes in the immune response contributes to the inflammation and progression of rheumatoid arthritis

5. Our results suggest that semaphorin 7a may be novel target for blocking breast tumor progression.

6. SEMA7A plays a critical role in IgE-mediated neutrophilic airway inflammation

7. SEMA7A has a role in the development of lung injury

8. Data suggest that sema7A is involved in the pathogenesis of experimental autoimmune encephalomyelitis, in the modulation of the immune response and in the neurodegeneration that take place in the CNS.

9. This study demonstrates that Sema7A controls the assembly of actin-based protrusions that drive Dendritic cell migration in response to CCL21 (show CCL21 Proteins).

10. Sem7a and its receptors regulate Chi3l1 (show CHI3L1 Proteins) in pulmonary melanoma metastasis

Human Semaphorin 7A, GPI Membrane Anchor (John Milton Hagen Blood Group) (SEMA7A) interaction partners

1. These findings indicate that Sema7A as a potent activator of T cells and monocytes in the immune response contributes to the inflammation and progression of rheumatoid arthritis

2. short hairpin-mediated silencing of SEMA7A reveals roles for semaphorin 7a in the promotion of DCIS growth, motility and invasion as well as lymphangiogenesis in the tumor microenvironment. Our studies also uncover a relationship between COX-2 and semaphorin 7a expression and suggest that semaphorin 7a promotes tumor cell invasion on collagen and lymphangiogenesis via activation of b1-integrin receptor

3. Our results identified FGL2 (show FGL2 Proteins), GAL (show GAL Proteins), SEMA4D (show SEMA4D Proteins), SEMA7A, and IDO1 (show IDO1 Proteins) as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2 (show FGL2 Proteins), GAL (show GAL Proteins), SEMA4D (show SEMA4D Proteins), SEMA7A, and IDO1 (show IDO1 Proteins) genes appeared to be differentially transcribed in the different MSC (show MSC Proteins) populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals

4. Sema3A (show SEMA3A Proteins) and sema7A expression correlated with the inflammatory activity of the multiple sclerosis (MS) lesions, suggesting their involvement in the immunological process that takes place in MS.

5. SEMA7A has a role in the development of lung injury

6. This study demonstrates that Sema7A controls the assembly of actin-based protrusions that drive Dendritic cell migration in response to CCL21 (show CCL21 Proteins).

7. These results suggest that SEMA7a plays a role as a CSF (show CSF2 Proteins) biomarkers associated with the conversion to clinically definite multiple sclerosis in clinically isolated syndromes patients

8. heterozygous missense variants in SEMA3A (show SEMA3A Proteins) and SEMA7A may modify the phenotype of Kallmann syndrome but most likely are not alone sufficient to cause the disorder

9. SEMA7A was expressed in the liver and was increased in the course of liver fibrosis, both in mice and in humans.

10. Semaphorin 7A is a potentially important modulator of eosinophil profibrotic functions in the airway remodeling of patients with chronic asthma.