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this study identifies CD37 as a tumor suppressor that directly protects against B cell lymphomagenesis
The CD37-targeted antibody-drug conjugate IMGN529 is highly active against human CLL and in a novel CD37 transgenic murine leukemia model.
The cellular defect that underlies poor cellular immune induction in CD37-defcient mice is impaired dendritic cell migration.
CD37 was required for the mobility and clustering of alpha(4)beta(1) integrins in the plasma membrane, thus regulating the membrane distribution of alpha(4)beta(1) integrin necessary for activation of the Akt (show AKT1 Proteins) survival pathway
CD37 protects against glomerular IgA deposition and renal pathology
The influence of CD37 in the early events of T cell receptor signaling demonstrates a regulato (show CD3E Proteins)ry role for CD37 in T cell proliferation.
CD37 and CD151 control DC-mediated T-cell activation by two different mechanisms: CD151 regulates co-stimulation whereas CD37 regulates peptide/MHC presentation
tetraspanin protein CD37 inhibits IgA responses and regulates the anti-fungal immune response.
CD37 is a critical determinant of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone outcome in diffuse large B-cell lymphoma.
Data indicate that cell differentiation antigen 37 (CD37) is well expressed and a potential drug target in acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)).
Data indicate that enhanced antibody-dependent cell cytotoxicity (ADCC) is observed against chronic lymphocytic leukemia cells and is sustained at concentrations of SMIP-016(GV) as low at 5E(-6) microg/mL on cells expressing minimal CD37 antigen.
Identify two tyrosine residues in tetraspanin CD37 directly mediating transduction of survival and apoptotic signals.
In the absence of both CD37 and Tssc6 (show TSPAN32 Proteins), immune function is further altered when compared with CD37- or Tssc6 (show TSPAN32 Proteins)-deficient transgenic mice, demonstrating a complementary role for these two molecules in cellular immunity.
CD37 cross-linking on human T cells transduces signals that lead to complete inhibition of CD3 (show CD3 Proteins)-induced T cell proliferation.
CD37 is important for dectin-1 (show CLEC7A Proteins) stabilization in APC (show APC Proteins) membranes and controls dectin-1 (show CLEC7A Proteins)-mediated IL-6 (show IL6 Proteins) production.
provide strong justification for CD37 as a therapeutic target and introduce small modular immunopharmaceuticals as a novel class of targeted therapies for B-cell malignancies
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.
leukocyte antigen CD37
, CD37 antigen
, cell differentiation antigen 37
, leukocyte surface antigen CD37