anti-Mouse (Murine) GABBR1 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended GABBR1 Antibody (supplied by: Log in to see )

Antigen
gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) Antibodies
  • GABABR1
  • GABBR1-3
  • GB1
  • GPRC3A
  • dJ271M21.1.1
  • dJ271M21.1.2
  • gabbr1
  • GABBR1
  • GABA(B)R1
  • GABAB1
  • GABAbR1
  • bM573K1.1
  • gamma-aminobutyric acid type B receptor subunit 1
  • gamma-aminobutyric acid (GABA) B receptor, 1a
  • gamma-aminobutyric acid (GABA) B receptor, 1
  • GABBR1
  • gabbr1a
  • gabbr1
  • Gabbr1
Epitope
AA 670-720
54
52
25
17
6
5
4
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
151
135
126
19
12
9
7
6
6
4
4
3
3
1
1
Host
Rabbit
105
63
6
4
2
1
Clonality
Polyclonal
Conjugate
This GABBR1 antibody is un-conjugated
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
142
64
46
25
24
22
13
4
2
2
2
1
Options
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Catalog No. ABIN669756
$ 306.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN800886 IF (p) Cy3 Rabbit IgG pSer923 Log in to see Polyclonal 0
1 ABIN800887 IF (p) Cy5 Rabbit IgG pSer923 Log in to see Polyclonal 0
1 ABIN800889 IF (p) Cy7 Rabbit IgG pSer923 Log in to see Polyclonal 0
1 ABIN800890 IF (p) FITC Rabbit IgG pSer923 Log in to see Polyclonal 0
1 ABIN800888 IF (p) Cy5.5 Rabbit IgG pSer923 Log in to see Polyclonal 0
1 ABIN877299 IF (p) Alexa Fluor 488 Rabbit IgG pSer923 Log in to see Polyclonal 0
1 ABIN877298 IF (p) Alexa Fluor 350 Rabbit IgG pSer923 Log in to see Polyclonal 0
1 ABIN877300 IF (p) Alexa Fluor 555 Rabbit IgG pSer923 Log in to see Polyclonal 0
1 ABIN877301 IF (p) Alexa Fluor 647 Rabbit IgG pSer923 Log in to see Polyclonal 0
1 ABIN2813494 IF (p) Alexa Fluor 594 Rabbit IgG pSer923 Log in to see Polyclonal 0
1 ABIN800883 IF (p) IHC (p) WB Rabbit IgG pSer923 Log in to see Polyclonal 0
1 ABIN5003069 IF (p) Alexa Fluor 680 Rabbit IgG pSer923 Log in to see Polyclonal 0
1 ABIN5003070 IF (p) Alexa Fluor 750 Rabbit IgG pSer923 Log in to see Polyclonal 0

General

Antigen gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) Antibodies
Epitope AA 670-720
(54), (52), (25), (17), (6), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(151), (135), (126), (19), (12), (9), (7), (6), (6), (4), (4), (3), (3), (1), (1)
Host Rabbit
(105), (63), (6), (4), (2), (1)
Clonality
Polyclonal
Conjugate This GABBR1 antibody is un-conjugated
(4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(142), (64), (46), (25), (24), (22), (13), (4), (2), (2), (2), (1)
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Product Details anti-GABBR1 Antibody

Target Details GABBR1 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human GABABR1
Isotype IgG

Target Details GABBR1

Product Details anti-GABBR1 Antibody Application Details Handling Images back to top
Antigen
Alternative Name GABABR1 (GABBR1 Antibody Abstract)
Background

Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Activated by (-)-baclofen, cgp27492 and blocked by phaclofen. Isoform 1E may regulate the formation of functional GABBR1/GABBR2 heterodimers by competing for GABBR2 binding. This could explain the observation that certain small molecule ligands exhibit differential affinity for central versus peripheral sites.

Subcellular location: Cytoplasm

Synonyms: GB1, GPRC3A, GABABR1, GABBR1-3, dJ271M21.1.1, dJ271M21.1.2, Gamma-aminobutyric acid type B receptor subunit 1, GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABBR1

Gene ID 2550
UniProt Q9UBS5
Pathways Positive Regulation of Peptide Hormone Secretion, cAMP Metabolic Process

Application Details

Product Details anti-GABBR1 Antibody Target Details GABBR1 Handling Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-GABBR1 Antibody Target Details GABBR1 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-GABBR1 Antibody Target Details GABBR1 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1) (AA 670-720) antibody (ABIN669756) Formalin-fixed and paraffin embedded: rat brain tissue labeled with Anti-GABRB1 Polyc...