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Cow (Bovine) Polyclonal GLUD1 Primary Antibody for IHC, WB - ABIN2782330
Kawajiri, Okano, Kuno, Tokuhara, Hase, Inada, Tashiro, Miyazaki, Yamano: Unregulated insulin secretion by pancreatic beta cells in hyperinsulinism/hyperammonemia syndrome: role of glutamate dehydrogenase, ATP-sensitive potassium channel, and nonselective cation channel. in Pediatric research 2006
Show all 3 Pubmed References
near-atomic resolution cryoelectron microscopy structures, at resolutions ranging from 3.2 A to 3.6 A for GDH complexes, is reported.
Data show that glutamate (show GRIN2A Antibodies) dehydrogenase activity in an enzymatic catalyzed reaction by tracing the increasing of oxidation current of NADH.
Data show that heat inactivation of the native GDH enzyme occurred with a rate constant of inactivation of 0.252 min-1 (show CD59 Antibodies).
the existence of two partially unfolded states of GDH at moderate acidic pHs (show PCBD1 Antibodies) which may be considered as molten and pre-molten globule-like states.
Characterized cDNA clones of sequences GDH1 and GDH2 (show GLUD2 Antibodies) that code for putative alpha- and beta-subunits of the NADH dependent enzyme. Although the gene transcripts are co-localized in roots of etiolated seedlings, the ratio of the two subunits varies among tissues.
structural model of a complex of human Sirt4 (show SIRT4 Antibodies) and GDH in order to elucidate the molecular mechanism underlying the ADP-ribosylation of GDH by Sirt4 (show SIRT4 Antibodies)
Upregulation of GLUD1 and SLC25A13 (show slc25a13 Antibodies) was associated with tumor aggressiveness and poorer prognosis in colorectal cancer patients.
This study showed that SIRT5 (show SIRT5 Antibodies) supports the anaplerotic entry of glutamine (show GFPT1 Antibodies) into the TCA cycle in malignant phenotypes of CRC (show CALR Antibodies) via activating GLUD1.
the present study shows that the GDHS445L enzyme is highly sensitive to the allosteric activator ADP, explaining the hyperactivity of this mutant. INS (show INS Antibodies)-1E beta-cells expressing GDHS445L responded to glutamine (show GFPT1 Antibodies) stimulation by increasing the mitochondrial respiration and ATP production, as well as by a rise in cytosolic calcium.
We have shown that alpha-ketoglutarate substrate inhibition kinetics of GDH, which include both random and obligatory ordered association/dissociation reactions, robustly control the ratio between glutamate (show GRIN1 Antibodies) and ammonium under a wide range of intracellular substrate variation. Dysregulation of this activity under pericentral nitrogen insufficiency contributes to the breaking down of ammonia homeostasis and thereby can s...
mRNA and protein levels of GluD1 were increased in iPSC-derived neurons (show FOXG1 Antibodies) from FOXG1(+/-) patients.
Hypoxia-induced expression of GDH relies on the up-regulation of HIF1alpha (show HIF1A Antibodies) but not HIF2alpha (show EPAS1 Antibodies). HIF1alpha (show HIF1A Antibodies) binds the promoter of GDH and promotes the transcription of GDH gene in lung cancer cells.
Results indicate that it is possible to use high-throughput screening methods to find activators for glutamate (show GRIN1 Antibodies) dehydrogenase (GDH) that might be useful as pharmaceutical agents.
Missense mutation of GLUD1 is associated with Hyperinsulinism-hyperammonemia syndrome.
GLUD1 is differentially expressed in the cellular and subcellular compartments of numerous tissues.
Findings demonstrate that hippocampal synapse assembly and maintenance require a tripartite molecular complex in which the ligand Cbln2 binds with presynaptic neurexin (show NRXN1 Antibodies) 1beta (+S4) and postsynaptic GluD1.
Data suggest that metabolism of glutamine (show GFPT1 Antibodies) and related analogs by Gdh (show UGDH Antibodies) in intestinal L-cells explains why Glp1 (show GCG Antibodies) secretion, but not that of insulin (show INS Antibodies) by pancreatic beta-cells, is activated by these secretagogues. (Gdh (show UGDH Antibodies) = glutamate (show GRIN1 Antibodies) dehydrogenase; Glp1 (show GCG Antibodies) = glucagon-like peptide 1 (show GCG Antibodies))
mRNA and protein levels of GluD1 were increased in fetal brain of foxg1 (show FOXG1 Antibodies)(+/-) mice. mRNA and protein levels of GluD1 were decreased in adult brain of foxg1 (show FOXG1 Antibodies)(+/-) mice.
lack of glutamate (show GRIN1 Antibodies) oxidation in brain-specific (show CALY Antibodies) GDH (show UGDH Antibodies) null CnsGlud1-/- mice resulted in a central energy-deprivation state with increased ADP/ATP ratios and phospho-AMPK (show PRKAA1 Antibodies) in the hypothalamus.
This study demonstrated a critical requirement for GluD1 in normal spine development in the cortex and hippocampus.
The GDH (show UGDH Antibodies) activity in mice is highest in the liver with NAD(+) as a coenzyme and highest GDH (show UGDH Antibodies) activity was determined at a glutamate (show GRIN1 Antibodies) concentration of 10 mM.
Age-related increases of glutamate (show GRIN1 Antibodies) were observed only in the striatum of the glutamate dehydrogenase 1 mice
Glutamate (show GRIN1 Antibodies) hyperactivity caused gene expression changes in the hippocampus at all ages
GluD1 regulates the connectivity of parallel fiber-interneuron synapses and promotes differentiation of interneurons.
The GDH1 is a key metabolic enzyme with emerging roles in insulin (show INS Antibodies) regulation. MitoNEET (show CISD1 Antibodies) forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator.
these data illustrate the essential role of EIN3-regulated GDH (show UGDH Antibodies) activity in metabolic adjustment during anoxia-reoxygenation.
the carboxyl terminus of the GDH (show UGDH Antibodies) subunit is involved in the stabilization of the oligomeric structure of the enzyme.
In leaves and stems of arabidopsis and tobacco, both the alpha- and beta-subunits of Glutamate (show GRIN2A Antibodies) dehydrogenase are targeted to the mitochondria of the companion cells.
GDH (show UGDH Antibodies) has a major effect on the control of metabolic composition during tomato fruit ripening, but not at other stages of development.
These results indicate that GDH (show UGDH Antibodies) beta-subunit (show POLG Antibodies) could modulate the heteromeric isoforms of GDH (show UGDH Antibodies) in response to the environment and physiology of the tomato fruit.
This gene encodes glutamate dehydrogenase protein\; a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid induced insulin secretion and activating mutations in this gene are a common cause of congenital hyperinsulinism. This enzyme is allosterically activated by ADP and inhibited by GTP and ATP. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Multiple pseudogenes of this gene are present in humans.
, glutamate dehydrogenase 1, mitochondrial
, glutamate dehydrogenase 1
, mitochondrial glutamate dehydrogenase 1
, glutamate dehydrogenase (NAD(P)+)
, memory-related gene 2 protein
, glutamate dehydrogenase 1, mitochondrial-like
, NADH-glutamate dehydrogenase
, glutamate dehydrogenase