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Human HIF1A Protein expressed in Wheat germ - ABIN1306618
Vadivel, Alphonse, Etches, van Haaften, Collins, OReilly, Eaton, Thébaud: Hypoxia-inducible factors promote alveolar development and regeneration. in American journal of respiratory cell and molecular biology 2014
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Studies demonstrate a role for HIF-1alpha in regulation of TSP2 (show THBS2 Proteins) expression via primarily a transcriptional mechanism.
HIF1alpha role in the cardiac hypertrophy, apoptosis, and fibrosis.HIF1alpha is partially inhibited in the cardiac fibrosis by p53 (show TP53 Proteins).
T3 thyroid hormone (show PTH Proteins) increased HIF-1alpha protein levels as well as steroid secretion in Leydig cells
Myeloid-specific deletion of Hif1a had no impact on the number of myeloid cells migrating into the eye.
HS-induced PPARalpha (show PPARA Proteins)-mediated downregulation of PHD1 (show EGLN2 Proteins) is a novel pathway for PHD (show PDC Proteins)/HIF-1alpha transcriptional regulation.
HIF1alpha promoted macrophage glycolysis metabolism, which induced M1 polarization in mice.
DAPK (show DAPK1 Proteins) deficiency leads to excess HIF-1a accumulation, enhanced IL-17 (show IL17A Proteins) expression and exacerbated experimental autoimmune encephalomyelitis.
activation of HIF signaling in osteoprogenitor cells increases blood levels of the chemokine C-X-C motif ligand 12 (show CXCL12 Proteins), which leads to a systemic increase of breast cancer cell proliferation and dissemination through direct activation of the CXCR4 (show CXCR4 Proteins) receptor
HIF regulation of HOIL-1L (show RBCK1 Proteins) targets the phosphorylated PKC-zeta (show PRKCZ Proteins) for degradation and serves as an hypoxia-adaptive mechanism to stabilize the Na,K-ATPase (show ATP1A1 Proteins), avoiding significant lung injury.
our study suggests that HIF1A is a common critical downstream mediator for HLH. We propose that HIF1A activation as the consequence of systemic inflammation, cytokine storm, or ligation of TLR may contribute to HLH development.
Knockdown of DEC2 (show BHLHE41 Proteins) resulted in a significant (26.7%) reduction of VEGF (show VEGFA Proteins) expression in MIO (show MLXIPL Proteins)-M1 cells under hypoxia-mimicking conditions induced by DFO (P < .05). Levels of HIF1alpha protein were also reduced significantly, by 60.2%, in MIO (show MLXIPL Proteins)-M1 cells treated with siRNA against the DEC2 (show BHLHE41 Proteins) gene (P < .05). Moreover, HIF1alpha levels showed a significant (2.5-fold) increase in MIO (show MLXIPL Proteins)-M1 cells overexpressing DEC2 (show BHLHE41 Proteins) (P < .05).
High HIF1A expression is associated with salivary adenoid cystic carcinoma.
we found that Hif-1alpha directly promoted H19 (show NCKAP1 Proteins) expression through binding to the H19 (show NCKAP1 Proteins) promoter and indirectly through SP1 (show PSG1 Proteins)-mediated H19 (show NCKAP1 Proteins) transcriptional activation under hypoxia in glioblastoma cells.
The IRIS-driven metastatic mechanism results from IRIS-dependent suppression of phosphatase and tensin homolog (PTEN) transcription, which in turn perturbs the PI3K/AKT/GSK-3beta pathway leading to prolyl hydroxylase-independent HIF-1alpha stabilization and activation in a normoxic environment.
Data show that von Hippel-Lindau-binding protein 1 (VBP1 (show PFDN3 Proteins)) enhances the stability of von Hippel-Lindau tumor suppressor protein (show TP53 Proteins) (pVHL (show VHL Proteins)) and facilitates pVHL (show VHL Proteins)-mediated ubiquitination of hypoxia-inducible factor 1, alpha subunit (show POLG Proteins) (HIF-1alpha).
Multifunctional proteins epigenetically modulating HIF1A stability and activity have been described. (Review)
Studies have shown that both HIF1alpha and HIF2alpha (show EPAS1 Proteins) may contribute to the regulation of cellular adaptation to hypoxia and resistance to cancer therapies with their potential to exert significant effects on the maintenance and evolution of cancer stem cells. Also, HIF1alpha and HIF2alpha (show EPAS1 Proteins) seemed to have significant prognostic and predictive value. [review]
HIF-1 was overexpressed in osteosarcoma tissues and cell lines, which promoted cell proliferation, clone formation, migration, invasion and inhibited cell apoptosis.
hypoxiainduced expression of CXCR4 (show CXCR4 Proteins) promoted trophoblast cell migration and invasion via the activation of HIF1alpha, which is crucial during placentation.
Data suggest that NRF2/NFE2L2 (show NFE2L2 Proteins) promotes breast cancer progression by enhancing glycolysis through co-activation of HIF1A; NRF2 (show GABPA Proteins) and HIF1A mRNA and protein levels are significantly up-regulated in breast cancer cells as compared to benign breast epithelial cells. (NRF2/NFE2L2 (show NFE2L2 Proteins) = nuclear factor erythroid 2-related factor 2 (show NFE2L2 Proteins); HIF1A = hypoxia inducible factor 1 subunit alpha)
results of the present study suggest that increases in hypoxia inducible factor 1 subunit alpha( HIF-1alpha) are responsible for initial response to hypoxia that results in a transient cell cycle arrest in trophectoderm cells
The results showed that 60-min ischemia of the porcine uterus conducted at the mid-secretory estrous phase caused decreased HIF-1alpha and increased SOD-2 (show SOD2 Proteins) gene expression.
a high expression of hypoxia induced factor-1a (HIF-1a) and heat shock protein 70 (HSP70 (show HSP70 Proteins)) was noted
Induction of ischemic osteonecrosis results in IL-6 (show IL6 Proteins) production in the articular cartilage through an HIF-1-dependent pathway.
Upregulation of VEGF (show VEGFA Proteins) during hypoxia in chondrocyte is mediated partially through HIF-1alpha.
HIF-1alpha activates Sox9 (show SOX9 Proteins) expression and enhances Sox9 (show SOX9 Proteins)-mediated transcriptional activity.
Intramyocardial delivery of mesenchymal stem cells seems to trigger the release of angiogenic HIF-1alpha more effectively than does intracoronary delivery.
immunostaining for HIF-1alpha and HIF-2alpha (show EPAS1 Proteins) was observed during endochondral ossification, whereas only HIF-2alpha (show EPAS1 Proteins) was present at sites of intramembranous ossification
Downregulation of miR (show MYLIP Proteins)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 (show SIRT1 Proteins) and recapitulates hypoxia preconditioning in cardiac myocytes.
Viable chondrocytes in the superficial layer of the epiphyseal cartilage showed HIF-1alpha activation and VEGF (show VEGFA Proteins) upregulation with subsequent revascularization occurring in the cartilage.
inverse expression and localization pattern of HIF1A and vasohibins during different stages of ovarian function in cow
Hypoxia increased the amounts of HIF1A protein, VEGF (show VEGFA Proteins) mRNA and VEGF (show VEGFA Proteins) protein in cultured bovine luteal cells.
hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity
VEGF (show VEGFA Proteins) has an effect on the expression of its own transcription factor, HIF-1, and on VEGF (show VEGFA Proteins) itself
Identify sphingosine-1-phosphate as a novel and potent nonhypoxic activator of HIF-1.
Suggest supplemental oxygen inhibits HIF-1alpha/VEGF (show VEGFA Proteins) signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.
HIF-1alpha-induced HSP70 (show HSP70 Proteins) overexpression increased the expression levels of ECM (show MMRN1 Proteins) genes and cell viability, and protected chondrocytes from apoptosis. HIF-1alpha may regulate anabolic effects of chondrocytes under hypoxic conditions by regulating HSP70 (show HSP70 Proteins) expression
Transcatheter arterial embolization of liver tumors increases the expression of HIF-1alpha at protein level in the residual viable tumor.
Upregulation of HIF-1 protects cardiac myocyte function after ischemia/reperfusion by maintaining calcium release.
HIF-1alpha expression in early atherosclerosis can promote the formation of neovascularization.
Xells respond to hypoxia through a transcription factor, hypoxia-inducible factor 1
Upregulation of HIF-1 could protect isolated cardiac myocytes against nitrate tolerance through a cyclic GMP protein kinase-independent mechanism and through a kinase-dependent mechanism in myocardial stunning.
rhEPO can down-regulate HIF-1alpha expression in the retina of rabbits with acute high intraocular pressure.
Increased HIF-1 alpha protects the functional effects of cyclic GMP thorough maintenance of cyclic GMP protein kinase activity after ischemic-reperfusion
Our results suggest that these detoxification pathways are mediated by the hypoxia inducible factor HIF-1. Finally, we show that sulfide (show SQRDL Proteins) resistance varies among wild C. elegans and other nematode species, suggesting that tolerance to sulfide (show SQRDL Proteins) was naturally selected in certain habitats.
blocking HIF-1 activity may promote survival in cells with compromised mitochondrial function.
HIF-1-mediated activation of 5-HT (show DDC Proteins) signalling promotes axon regeneration by activating both the RhoA (show RHOA Proteins) and cAMP pathways.
this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2 (show FMO2 Proteins)).
AMPK (show PRKAA1 Proteins) and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS (show ROS1 Proteins)
Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1.
Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK (show PRKAA1 Proteins) compromised C. elegans dauer larvae.
These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.
Data indicate that genes sqrd-1, ethe-1 (show ETHE1 Proteins), cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide (show SQRDL Proteins) and hydrogen cyanide.
Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner.
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
, HIF1 alpha
, Hypoxia-inducible factor 1 alpha
, hypoxia-inducible factor 1-alpha
, ARNT-interacting protein
, ARNT interacting protein
, PAS domain-containing protein 8
, basic-helix-loop-helix-PAS protein MOP1
, class E basic helix-loop-helix protein 78
, hypoxia-inducible factor 1 alpha isoform I.3
, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
, hypoxia-inducible factor1alpha
, member of PAS protein 1
, member of PAS superfamily 1
, hypoxia-inducible factor 1 alpha
, hypoxia inducible factor 1 alpha subunit
, hypoxia inducible factor 1, alpha subunit